The Role of Whole Islets in T1D

In this episode, Christopher Moraes, PhD, joins us to discuss multi scale microenvironment control in stem cell-derived pancreatic progenitor production.

In this episode, Christopher Moraes joins us to discuss multi scale microenvironment control in stem cell-derived pancreatic progenitor production.

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Multiscale Microenvironment Control in Stem Cell-Derived Pancreatic Progenitor Production

The Sugar Science January 27, 2026 2:19 pm

In this episode, Ulf Ahlgren joins us to discuss Islet Cellularity in Health and Type 1 Diabetes: insights from deep tissue 3D imaging.

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Islet Cellularity in Health & Type 1 Diabetes: insights from deep tissue 3D imaging-Ulf Ahlgren, PhD

The Sugar Science January 20, 2026 9:40 am

In this episode, Katy Murrall from the Richardson Lab joins us to discuss small things matter: lack of extra islet beta cells in type 1 diabetes.

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Small Things Matter: Lack of Extra Islet Beta Cells in T1D - Katy Murall, PhD, University of Exeter

The Sugar Science December 17, 2025 8:01 am

In this episode, Julia Wang, PhD, joins us to discuss molecular mechanisms of human pancreatic islet dysfunction under overnutrition metabolic stress.

In this episode, Julia Wang joins us to discuss molecular mechanisms of human pancreatic islet dysfunction under overnutrition metabolic stress.

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Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress

The Sugar Science November 20, 2025 9:36 am

In this episode, Stephan Ramos, PhD, Stanford University joins us to discuss hematopoietic stem cell transplantation promotes islet transplant tolerance and diabetes reversal.

In this episode, Stephan Ramos joins us to discuss hematopoietic stem cell transplantation promotes islet transplant tolerance and diabetes reversal.

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Hematopoietic Stem Cell Transplantation Promotes Islet Transplant Tolerance & Diabetes Reversal

The Sugar Science October 22, 2025 10:38 pm

In this episode, Luc Teyton joins us to discuss how to understand the initiation of type 1 diabetes.

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How to Understand the Initiation of Type 1 Diabetes - Luc Teyton, MD PhD, Scripps

The Sugar Science October 9, 2025 10:20 am

In this episode, Shuibing Chen, PhD, & Stephen Parker, PhD, join us to discuss Integrative single-cell multi-omics profiling of human pancreatic islets identifies TID-associated genes and regulatory signals.

In this episode, Shuibing Chen & Stephen Parker join us to discuss Integrative single-cell multi-omics profiling of human pancreatic islets identifies TID-associated genes and regulatory signals.

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Integrative sc Multi-omics Profiling of Pancreatic Islets Identifies TID Genes & Regulatory Signals

The Sugar Science September 30, 2025 2:56 pm

In this episode, Nikki Farnsworth joins us to discuss stressed beta-cells contribute to a loss of peri-islet extracellular matrix in type 1 diabetes.

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T1D Th1nk Tank: Nikki Farnsworth, PhD, Colorado School of Mines

The Sugar Science August 26, 2025 6:20 am

In this episode, Clayton Mathews joins us to discuss identifying real changes in islets and beta cells during progression to type 1 diabetes.

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T1D Th1nk Tank: Clayton Mathews, PhD, University of Florida

The Sugar Science July 23, 2025 2:03 pm

In this episode, Marcus Lundberg joins us to discuss the islet delta-cell architecture is remodeled in the human pancreas during Type 1 Diabetes.

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T1D Th1nk Tank: Marcus Lundberg, MD PhD, Uppsala University

The Sugar Science July 9, 2025 5:46 am

In this episode, Mohammad Pourhosseinzadeh joins us to discuss heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals/low-density cx36 gap junctions.

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T1D Th1nk Tank: Mohammad Pourhosseinzadeh, MD PhD, UC Davis

The Sugar Science June 12, 2025 4:08 pm

In this episode, Thomas Hill joins us to discuss loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycemia-induced glucagon secretion in type-1 diabetes.

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T1D Think Tank: Thomas Hill, PhD, University of Oxford

The Sugar Science May 1, 2025 6:26 pm

In this episode, Theodore dos Santos a PhD candidate in the MacDonald research group at Alberta Diabetes institute joins us to discuss linking molecular pathways and islet cell dysfunction in human type 1 diabetes.

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T1D Th1nk Tank: Theodore dos Santos, PhD Candidate, Alberta Diabetes Institute

The Sugar Science May 1, 2025 2:46 pm

In this episode, Abdelfattah El Quaamari discusses Sensory-Islet Crosstalk in Glucose Homeostasis.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #sensory #islet #isletcrosstalk #crosstalk #glucosehomeostasis #glucose #glucosecontrol #pancreasimaging #pancreas

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Ask the Expert: Abdelfattah El Quaamari, PhD, New York Medical College

The Sugar Science December 17, 2024 2:15 pm

In this episode, Matthew Merrins from University of Wisconsin-Madison and Richard Benninger from University of Colorado discuss 3D light-sheet imaging of the islet: New insights into the beta cell subpopulations that lead and coordinate Ca2+ oscillations.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #betacells #3dlightimaging #pancreas #pancreaticimaging #calcium #calciumoscillations #betacellsubpopulations

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Ask the Expert: Matthew Merrins, PhD, & Richard Benninger, PhD, 3D light-sheet imaging of the islet

The Sugar Science October 21, 2024 1:13 pm

In this episode, Andreas Müller joins us to discuss a great listener: The primary cilium as an antenna for islet intrinsic and extrinsic signals.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #cilia #primarycilium #islet #intrinsicsignals #extrinsicsignals #signaling

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Ask the Expert: Andreas Müller, PhD, Paul Langerhans Institute Dresden

The Sugar Science October 21, 2024 12:50 pm

Join us for the site visit at Vanderbilt School of Medicine as we talk to:
Marcela Brissova, PhD
Angela Kruse, PhD
David Jacobson, PhD
Jeeyeon Cha, MD PhD

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Site Visit Vanderbilt SOM: Insights into T1D Pathogenesis - Islet Perspective

The Sugar Science October 10, 2024 10:24 pm

In this episode, Jeffrey Millman discusses identification of unique cell type responses in pancreatic islets to stress.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #pancreaticislets #islets #isletstress #uniquecelltype #cells #pancreas

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Ask the Expert: Jeffrey Millman, PhD, Washington University at St. Louis

The Sugar Science September 21, 2024 4:45 pm

In this episode, Joana Almaça discusses pericytes and vascular control of islet function.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #pericytes #vascularcontrol #islet #isletfunction #pancreas

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Ask the Expert: Joana Almaça, PhD, University of Miami

The Sugar Science May 30, 2024 3:26 pm

In this episode, Romina Bevacqua discusses CRISPR Gene Editing in Primary Human Islet Organoids.

#organoids #CRISPR #geneediting #crisprgeneediting #primaryhumanisletorganoids #humanislets #islets #pancreas #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

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Ask the Expert: Romina Bevacqua, PhD, Mount Sinai

The Sugar Science December 22, 2023 5:17 pm