The Role of Whole Islets in T1D

In this episode, Ulf Ahlgren joins us to discuss Islet Cellularity in Health and Type 1 Diabetes: insights from deep tissue 3D imaging.

In this episode, Katy Murrall from the Richardson Lab joins us to discuss small things matter: lack of extra islet beta cells in type 1 diabetes.

In this episode, Julia Wang joins us to discuss molecular mechanisms of human pancreatic islet dysfunction under overnutrition metabolic stress.

In this episode, Stephan Ramos joins us to discuss hematopoietic stem cell transplantation promotes islet transplant tolerance and diabetes reversal.

In this episode, Luc Teyton joins us to discuss how to understand the initiation of type 1 diabetes.

In this episode, Shuibing Chen & Stephen Parker join us to discuss Integrative single-cell multi-omics profiling of human pancreatic islets identifies TID-associated genes and regulatory signals.

In this episode, Nikki Farnsworth joins us to discuss stressed beta-cells contribute to a loss of peri-islet extracellular matrix in type 1 diabetes.

In this episode, Clayton Mathews joins us to discuss identifying real changes in islets and beta cells during progression to type 1 diabetes.

In this episode, Mohammad Pourhosseinzadeh joins us to discuss heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals/low-density cx36 gap junctions.

In this episode, Thomas Hill joins us to discuss loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycemia-induced glucagon secretion in type-1 diabetes.

In this episode, Theodore dos Santos a PhD candidate in the MacDonald research group at Alberta Diabetes institute joins us to discuss linking molecular pathways and islet cell dysfunction in human type 1 diabetes.

In this episode, Abdelfattah El Quaamari discusses Sensory-Islet Crosstalk in Glucose Homeostasis.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #sensory #islet #isletcrosstalk #crosstalk #glucosehomeostasis #glucose #glucosecontrol #pancreasimaging #pancreas

In this episode, Matthew Merrins from University of Wisconsin-Madison and Richard Benninger from University of Colorado discuss 3D light-sheet imaging of the islet: New insights into the beta cell subpopulations that lead and coordinate Ca2+ oscillations.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #betacells #3dlightimaging #pancreas #pancreaticimaging #calcium #calciumoscillations #betacellsubpopulations

In this episode, Andreas Müller joins us to discuss a great listener: The primary cilium as an antenna for islet intrinsic and extrinsic signals.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #cilia #primarycilium #islet #intrinsicsignals #extrinsicsignals #signaling

Join us for the site visit at Vanderbilt School of Medicine as we talk to:
Marcela Brissova, PhD
Angela Kruse, PhD
David Jacobson, PhD
Jeeyeon Cha, MD PhD

In this episode, Jeffrey Millman discusses identification of unique cell type responses in pancreatic islets to stress.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #pancreaticislets #islets #isletstress #uniquecelltype #cells #pancreas

In this episode, Joana Almaça discusses pericytes and vascular control of islet function.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #pericytes #vascularcontrol #islet #isletfunction #pancreas

In this episode, Romina Bevacqua discusses CRISPR Gene Editing in Primary Human Islet Organoids.

#organoids #CRISPR #geneediting #crisprgeneediting #primaryhumanisletorganoids #humanislets #islets #pancreas #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

Ruth Elgamal from the Kyle Gaulton lab at UCSD joins us to discuss an integrated pancreatic islet reference map: creating accessible tools and resources.

Dr. Ed Phelps from University of Florida joins us to discuss pancreas slices to study interactions between immune cells and islets.