The Role of Whole Islets in T1D

In this episode, Juan Alvarez joins us to discuss Flexible Electronic Implanted Cyborg Organoids Reveal Principles of Human Islet Cell Electrical Maturation.

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Flexible Electronic Implanted Cyborg Organoids Reveal Principles of Islet Cell Electrical Maturation

The Sugar Science August 9, 2026 3:18 pm

In this episode, Camillo Bechi Genzano from Colombia University joins us to discuss Thymic selection of multiple islet antigen-reactive HLA class II-restricted human T cell clones.

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Thymic selection of multiple islet antigen-reactive HLA class II-restricted human T cell clones

The Sugar Science July 30, 2026 2:17 pm

In this episode, Dingy Liu PhD Candidate in the Huangfu Lab at MSK joins us to discuss When Beta Cell Specification Fails: A Knockout Village Reveals Lineage Rewiring in Human Islets.

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When Beta Cell Specification Fails: A Knockout Village Reveals Lineage Rewiring in Human Islets

The Sugar Science July 16, 2026 8:19 am

In this episode, Austin Stis PhD Candidate in Ed Phelp's lab in University of Florida joins us to discuss Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets.

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Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets-Austin Stis PhD

The Sugar Science June 25, 2026 7:44 am

In this episode, Hirotake Komatsu, MD PhD, and Peter Stock, MD PhD, both from UCSF join us to discuss From Oxygen Limitation to Opportunity: Defining Hypoxia Resistance in stem cell derived and primary Islets.

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From Oxygen Limitation to Opportunity: Defining Hypoxia Resistance in Pancreatic Islets

The Sugar Science May 25, 2026 9:20 pm

In this episode, Christopher Moraes, PhD, joins us to discuss multi scale microenvironment control in stem cell-derived pancreatic progenitor production.

In this episode, Christopher Moraes joins us to discuss multi scale microenvironment control in stem cell-derived pancreatic progenitor production.

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Multiscale Microenvironment Control in Stem Cell-Derived Pancreatic Progenitor Production

The Sugar Science January 27, 2026 2:19 pm

In this episode, Ulf Ahlgren joins us to discuss Islet Cellularity in Health and Type 1 Diabetes: insights from deep tissue 3D imaging.

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Islet Cellularity in Health & Type 1 Diabetes: insights from deep tissue 3D imaging-Ulf Ahlgren, PhD

The Sugar Science January 20, 2026 9:40 am

In this episode, Katy Murrall from the Richardson Lab joins us to discuss small things matter: lack of extra islet beta cells in type 1 diabetes.

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Small Things Matter: Lack of Extra Islet Beta Cells in T1D - Katy Murall, PhD, University of Exeter

The Sugar Science December 17, 2025 8:01 am

In this episode, Julia Wang, PhD, joins us to discuss molecular mechanisms of human pancreatic islet dysfunction under overnutrition metabolic stress.

In this episode, Julia Wang joins us to discuss molecular mechanisms of human pancreatic islet dysfunction under overnutrition metabolic stress.

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Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress

The Sugar Science November 20, 2025 9:36 am

In this episode, Stephan Ramos, PhD, Stanford University joins us to discuss hematopoietic stem cell transplantation promotes islet transplant tolerance and diabetes reversal.

In this episode, Stephan Ramos joins us to discuss hematopoietic stem cell transplantation promotes islet transplant tolerance and diabetes reversal.

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Hematopoietic Stem Cell Transplantation Promotes Islet Transplant Tolerance & Diabetes Reversal

The Sugar Science October 22, 2025 10:38 pm

In this episode, Luc Teyton joins us to discuss how to understand the initiation of type 1 diabetes.

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How to Understand the Initiation of Type 1 Diabetes - Luc Teyton, MD PhD, Scripps

The Sugar Science October 9, 2025 10:20 am

In this episode, Shuibing Chen, PhD, & Stephen Parker, PhD, join us to discuss Integrative single-cell multi-omics profiling of human pancreatic islets identifies TID-associated genes and regulatory signals.

In this episode, Shuibing Chen & Stephen Parker join us to discuss Integrative single-cell multi-omics profiling of human pancreatic islets identifies TID-associated genes and regulatory signals.

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Integrative sc Multi-omics Profiling of Pancreatic Islets Identifies TID Genes & Regulatory Signals

The Sugar Science September 30, 2025 2:56 pm

In this episode, Nikki Farnsworth joins us to discuss stressed beta-cells contribute to a loss of peri-islet extracellular matrix in type 1 diabetes.

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T1D Th1nk Tank: Nikki Farnsworth, PhD, Colorado School of Mines

The Sugar Science August 26, 2025 6:20 am

In this episode, Clayton Mathews joins us to discuss identifying real changes in islets and beta cells during progression to type 1 diabetes.

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T1D Th1nk Tank: Clayton Mathews, PhD, University of Florida

The Sugar Science July 23, 2025 2:03 pm

In this episode, Marcus Lundberg joins us to discuss the islet delta-cell architecture is remodeled in the human pancreas during Type 1 Diabetes.

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T1D Th1nk Tank: Marcus Lundberg, MD PhD, Uppsala University

The Sugar Science July 9, 2025 5:46 am

In this episode, Mohammad Pourhosseinzadeh joins us to discuss heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals/low-density cx36 gap junctions.

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T1D Th1nk Tank: Mohammad Pourhosseinzadeh, MD PhD, UC Davis

The Sugar Science June 12, 2025 4:08 pm

In this episode, Thomas Hill joins us to discuss loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycemia-induced glucagon secretion in type-1 diabetes.

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T1D Think Tank: Thomas Hill, PhD, University of Oxford

The Sugar Science May 1, 2025 6:26 pm

In this episode, Theodore dos Santos a PhD candidate in the MacDonald research group at Alberta Diabetes institute joins us to discuss linking molecular pathways and islet cell dysfunction in human type 1 diabetes.

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T1D Th1nk Tank: Theodore dos Santos, PhD Candidate, Alberta Diabetes Institute

The Sugar Science May 1, 2025 2:46 pm

In this episode, Abdelfattah El Quaamari discusses Sensory-Islet Crosstalk in Glucose Homeostasis.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #sensory #islet #isletcrosstalk #crosstalk #glucosehomeostasis #glucose #glucosecontrol #pancreasimaging #pancreas

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Ask the Expert: Abdelfattah El Quaamari, PhD, New York Medical College

The Sugar Science December 17, 2024 2:15 pm

In this episode, Matthew Merrins from University of Wisconsin-Madison and Richard Benninger from University of Colorado discuss 3D light-sheet imaging of the islet: New insights into the beta cell subpopulations that lead and coordinate Ca2+ oscillations.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #betacells #3dlightimaging #pancreas #pancreaticimaging #calcium #calciumoscillations #betacellsubpopulations

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Ask the Expert: Matthew Merrins, PhD, & Richard Benninger, PhD, 3D light-sheet imaging of the islet

The Sugar Science October 21, 2024 1:13 pm