In this episode, Samuel Stephens joins us to discuss Proinflammatory cytokines mediate pancreatic β-cell specific alterations to Golgi integrity via iNOS-dependent mitochondrial inhibition.

#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #type1diabetesresearch #betacells #golgi #mitochondrialinhibition #cytokines #proinflammatorycytokines #inflammation

In this episode, Ulf Hannelius joins us to discuss translating genetic insights into clinical progress - the evolution of Diamyd Medical's antigen-specific immunotherapy.

#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #diamydmedical #diamyd #antigenimmunotherapy #antigen #clinicalprogress #type1diabetesresearch

In this episode, Daniel Veronese-Paniagua a 6th year grad student part of the Millman lab discusses investigating the effects of coxsackievirus B3 infection on the various islet cell types.

#type1diabetes #type1diabetesresearch #t1d #novel #science #diabetesresearch #diabetes #research #islets #infectiousdisease #virus #coxsackie #handfootmouthdisease #coxsackievirus

In this episode, Xin Chen from the Mark Davis Lab at Stanford discusses differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses.

#type1diabetes #type1diabetesresearch #t1d #novel #science #diabetesresearch #diabetes #research #cd4tcells #cd8tcells #tregs #selfreactive #immuneresponse #immunology

In this episode, Matthew and Puchong discuss alpha-CD226 suppresses diabetes development in the NOD Mouse by augmenting Treds and diminishing effector T cell function.

In this episode, Ernesto Nakayasu discusses the Yin and Yang of fatty acids in regulating β-cell inflammation.

In this episode, Drs. Leeana Peters, Ed Phelps, Jessie Barra, and Cherie Stabler join us to discuss Innovations in Cellular Engineering at UFDI.

In this episode, Mollie Huber discusses Beta Cell Dysfunction During T1D Pathogenesis.

#ScienceTh1nkTank #ScientificResearch #BiomedicalScience #ResearchTalk #Type1Diabetes #BetaCells #DiabetesResearch #T1D #PancreaticIslets #MollieHuberPhD #UFResearch #JoslinDiabetesCenter #UniversityOfFlorida #HumanPancreasSlices #BetaCellFunction #ImmuneCellActivity #T1DPathogenesis

In this episode, Sonja Schrepfer MD PhD and Per-Ola Carlsson MD PhD from Sana Biotech discuss update on first in-human study of hypo immune islet cell transplantation in type 1 diabetes.

In this episode, Heba Ismail joins us to discuss the gut microbiome and metabolome in obesity and type 1 diabetes.

#type1diabetes #type1diabetesresearch #t1d #gutmicrobiome #gutmicrobiota #guthealth #obesity #metabolome #gutmetabolome #microbiome #research #microbiomeresearch

In this episode, Andrew Templin joins us to discuss novel roles for RIP kinases in beta-cell cytotoxicity.

#type1diabetes #type1diabetesresearch #t1d #RIPkinases #kinases #betacell #betacellstress #betacellcytotoxicity

In this episode, Erica Cai joins us to discuss genome-wide in vivo CRISPR screen uncovers ZBED3 as a transcriptional regulator of beta cell vulnerability in type 1 diabetes.


#type1diabetes #type1diabetesresearch #t1d #CRISPR #CRISPRscreen #betacell #betacellvulnerability #transcriptionalregulator #genomewidescreen #invivo #ZBED3

In this episode, Jamie Felton joins us to discussing betting on the B team: a case for targeting B cells in type 1 diabetes progression.

#type1diabetes #type1diabetesresearch #t1d #Bcells #diseaseprogression #targetingbcells #diabetesprogression

In this episode, Matthew Austin joins us to discuss dysfunctional beta-cell autophagy induces beta-cell stress and enhances islet immunogenicity.

#type1diabetes #type1diabetesresearch #immunogenicity #islet #betacell #betacellstress #autophagy #dysfunction #dysfunctionalbetacells #stress #t1d

In this episode, Madeline McLaughlin joins us to discuss ultra-high resolution imaging enables quantification of beta cell ER.

#type1diabetes #type1diabetesresearch #imaging #highresolutionimaging #ultrahighresolution #quantification #betacell #betacellER #ER #endoplasmicreticulum #t1d

In this episode, Chaitra Rao joins us to discuss the role of EV PD-L1 in Type 1 Diabetes Dynamics during the Indiana University site visit.

#type1diabetes #type1diabetesresearch #EV #extracellularvesicles #PDL1 #diabetesdynamics #t1d #tcells

At this remote site visit with Indiana University SOM we discuss Type 1 Diabetes Moonshot at IU including discussions about pathology, biomarkers, and clinical translation.

#type1diabetes #type1diabetesresearch #mRNA #riskmarkers #riskscore #biomarkers #HLA #haplotypes #diabetesrisk #diabetesriskscore

In this episode, Anand Hardikar discusses development of a microRNA-based Dynamic Risk Score for T1D.

T1D Th1nk Tank is discussions to fuel novel hypotheses, protocols and collaboration in T1D Research.

#type1diabetes #type1diabetesresearch #t1d #novel #science #miRNA #microRNA #riskscore #t1drisk #t1driskscore #biomarkers

In this episode, Nish Reddy discusses Engineering Immune Suppressor Cells: Designing Cellular Programs to Treat Inflammatory Diseases.

T1D Th1nk Tank is discussions to fuel novel hypotheses, protocols and collaboration in T1D Research.

#type1diabetes #type1diabetesresearch #t1d #novel #science #engineering #immunesuppressorcells #immunesystem #inflammatorydisease #cellularprograms #reprogramming

In this episode, Mai Tran discusses Mechanism for cross-reactivity of T cell receptors with InsC-peptide and hybrid insulin peptides presented by HLA-DQ8.

#type1diabetes #type1diabetesresearch #t1d #novel #science #insulinpeptide #peptide #DQ8 #haplotype #HLA #TCR #Tcellreceptor #crossreactivity

In this episode, Puneet Rawat discusses Understanding the role of T-cell receptor repertoire in T1D status.

T1D Th1nk Tank is discussions to fuel novel hypotheses, protocols and collaboration in T1D Research.

#type1diabetes #type1diabetesresearch #t1d #novel #science #TCR #Tcellreceptor #repertoire #TCRrepertoire

In this episode, Abdelfattah El Quaamari discusses Sensory-Islet Crosstalk in Glucose Homeostasis.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #sensory #islet #isletcrosstalk #crosstalk #glucosehomeostasis #glucose #glucosecontrol #pancreasimaging #pancreas

In this episode, Emmanuel Bosi discusses the Italian law on screening for type 1 diabetes and celiac disease in the general pediatric population: an update fall 2024.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #italianlaw #screening #celiacdisease #generalpediatrics #fall2024

In this episode, Jon Mentxaka discusses LncRNA-deprived peptides as a new source of auto reactive T cell epitopes in type 1 diabetes.

In this episode, Paul Thomas discusses T cell receptor pipelines for type 1 diabetes.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #tcrbeta #tcr #tcellreceptor #tcells #repertoire #TCR #pipeline

In this episode, Iria Gomez-Touriño discusses physiological and pathogenic T cell auto reactivity converge in type 1 diabetes.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #tcrbeta #tcr #tcellreceptor #tcells #repertoire #autoreactivetcells

In this episode, Zachary Freyberg discusses Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #dopamine #newtools #peripheraldopamine #D2likereceptor #dopaminereceptor #dysglycemia #signaling

In this episode, Raghu Mirmira and Sarah Tersey discuss 12-Lipoxygenase Inhibition delays autoimmune diabetes in human gene replacement mice.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #humangene #mice #micestudies #12LOX

In this episode, Jia Zhao discusses stem cell-derived islet models generated with a tunable differentiation strategy.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #islet #isletmodels #tunabledifferentiation #stemmcell #stemcellmodel #modelsystem #diabetesmodel #diabetesmodelsystem

In this episode, Marjan Slak Rupnik discusses Intracellular Ca2+ flux interactions in beta cells.

#askthexpert #ATE #type1diabetes #t1d #betacells #pancreas #calcium #calciumflux #intracellularcalcium #novel #science #diabetes #diabetesresearch #t1dresearch

In this episode, Peter Linsley discusses alpha-centric TCRs in Type 1 Diabetes

In this episode, Matthew Merrins from University of Wisconsin-Madison and Richard Benninger from University of Colorado discuss 3D light-sheet imaging of the islet: New insights into the beta cell subpopulations that lead and coordinate Ca2+ oscillations.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #betacells #3dlightimaging #pancreas #pancreaticimaging #calcium #calciumoscillations #betacellsubpopulations

In this episode, Andreas Müller joins us to discuss a great listener: The primary cilium as an antenna for islet intrinsic and extrinsic signals.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #cilia #primarycilium #islet #intrinsicsignals #extrinsicsignals #signaling

Join us for the site visit at Vanderbilt School of Medicine as we talk to:
Marcela Brissova, PhD
Angela Kruse, PhD
David Jacobson, PhD
Jeeyeon Cha, MD PhD

Join us for the site visit at Vanderbilt School of Medicine as we talk to:
Daniel Moore, MD PhD
Dudley McNitt, PhD
Christopher Wilson, PhD
Al Powers, MD

Join us for the site visit at Vanderbilt School of Medicine as we talk to:
Moderator: Al Powers, MD
Daniel Moore, MD PhD
Bill Russell, MD

In this episode, Danielle Dean joins us to discuss what makes an alpha cell an alpha cell and how we can use what we learn to treat type 1 diabetes.

#type1diabetes #t1d #TSS #sitevisit #asktheexpert #ATE #vanderbilt #vandy #VUMC #vanderbiltschoolofmedicine #alphacells #pancreas #betacells #islets #alpha

Development of Culturally Tailored Diabetes Technology Education for Black and Hispanic Adults with T1D - Kathryn Fantasia, MD MSc

Diabetes Care Access for Adolescents and Young Adults in Rural Areas - Daniel Tilden, MD, MPH

Predicting and Preventing Diabetic Ketoacidosis in Adults with Type 1 Diabetes Mellitus - Jacob Kohlenberg, MD

Type 1 Diabetes Prevention Using mRNA Immunotherapy - Timothy Foster, MD

Factors Contributing to Underutilization of Medical Nutrition Therapy in Pediatric Type 1 Diabetes - Svetlana Above, MD

Biomarkers of Neurodegeneration and Cognitive Performance in Young Adults with Type 1 Diabetes - Meghan Pauley, DO

In this episode, Tarun Pant discusses monocyte populations in type 1 diabetes families exhibit high activity and subset abundances that correlation with clinical progression

In this episode, Jeffrey Millman discusses identification of unique cell type responses in pancreatic islets to stress.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #pancreaticislets #islets #isletstress #uniquecelltype #cells #pancreas

In this episode, Alessandra Petrelli discusses a multi-omics integration approach relying on circulating factors does not discern endotypes in childhood type 1 diabetes.

#asktheexpert #ATE #endotypes #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #childhooddiabetes #omics #multiomics #t1dendotypes

Dr. Anoop Arunagiri joins us to discuss the contributors to proinsulin misfolding in pancreatic beta cells!

#t1d #science #proinsulin #proinsulinmisfolding #proteinmisfolding #erstress #pancreas #betacells #transcription #translation

In this episode, Melissa Akguen discusses resolving human α versus β cell fate allocation for the generation of stem cell-derived islets.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #alphacells #betacells #stemcells #stemcellmodel #islets #stemcellislets

Join us as Dr. Oliver Harrison discusses tracking immunity to gut microbes!

#science #guthealth #microbiome #microbiology #type1diabetes #immunity #immunology #immunehealth

Dr. Lowri Allen joins us to discuss relative maternal protection against T1D in offspring as compared with paternal disease!

#science #t1d #genetics #epigenetics #asktheexpert #medicaleducation #type1diabetes #methylation

In this episode, Abhijeet Patil PhD discusses Modeling Type 1 Diabetes Progression using Machine-learning and Single-cell Transcriptomic Measurements in Human Islets.

In this episode, Kagan Ege Karakus, MD, joins us to discuss Tirzepatide use in T1D.

#Tirzepatide #Type1Diabetes #T1D #DiabetesManagement #HbA1c #BodyMassIndex #BMI #ContinuousGlucoseMonitoring #CGM #TimeInRange #TIR #TimeInTightTargetRange #TITR #DiabetesResearch #GLP1RA #GlucagonLikePeptide #Efficacy #Safety #ClinicalStudy #MedicalResearch #DiabetesCare

In this episode, Alok Joglekar PhD discusses Dissecting the autoimmune repertoires in Type 1 Diabetes.

#autoimmune #t1d ##novel #science #noveldrug #thesugarscience #biomedicalsciences #immunology #tcells #TCRs #computationalbiology #systemsbiology #antigen #human #Universityofpittsburg

In this episode, Eunike Setyono discusses generating future SC-islets product for islet replacement therapy.

#stemcells #SCislets #islettransplantation #isletreplacement #therapy #stemcelltherapy #asktheexpert #t1d ##novel #science #type1diabetes

In this episode, Anath Shalev discusses TIX100 - a novel oral T1D drug - gets IND approval from FDA.

#FDAapproval #TIX100 #clinicaltrials #T1Dtreatment #T1Ddrug #asktheexpert #t1d ##novel #science #noveldrug

In this episode, Kevin Bode discusses Beta cell engineering to resist and counteract autoimmunity.

#betacells #betacellengineering #autoimmunity #asktheexpert #t1d #immunology #tcell #novel #science

Dr. Maria Ruiz joins us to discuss predictive signatures of HLA types from T-cell repertoires.

#asktheexpert #t1d #HLAtypes #immunology #tcell #immuneresponse #MHCrestriction #tcrs #novel #science

In this episode, Dr. Keiichiro Mine discusses the role of tyrosine kinase 2 in the pathogenesis of Type 1 diabetes.

#asktheexpert #type1diabetes #tyrosinekinase2 #science #geneediting #education #t1d #viralinfection #autoimmunedisease #betacells #tcell #dedifferentiation #islets #pancreas

One hour panel discussion of new tool:
HumanIslets: An integrated platform for human islet data access and analysis

Included the following scientists:
Jessica Ewald, PhD
Patrick MacDonald, PhD

In this episode, Inna Starskaia in the lab of Dr. Riitta Lahesmaa discusses distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #immuneresponse #autoantibodies @zntransporter #autoantibodiesinchildren #turku #TurkuBioscienceCentre

In this episode, Andrea Annoni discusses gene transfer-based strategies for the induction of Ag-specific immune tolerance in Type 1 Diabetes.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #antigens #antigenspecifictherapy #immunetolerance #immunesystem #antigeninduction #genetherapies #genestrategies

In this episode, Xavier Gidrol & Emily Tubbs discuss promises and challenges in pancreatic organoid development.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #pancreas #pancreaticorganoid #organoid #organoiddevlopment #stemcell #stemcellresearch

In this episode, David Perna-Barrull discusses Unveiling the Immune Dance: Macrophages role in Type 1 Diabetes immunotherapy.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #immunotherapy #macrophages #immunedance #macrophage #innateimmunity #monocytes #unveil

In this episode, Nick Thomas discusses Adult onset type 1 diabetes: Insights and unanswered questions.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #questions #unansweredquestions #adultonset #adultt1d #adultonsett1d

In this episode, James Pearson discusses Circadian influences on Tregs in Type 1 diabetes.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #tregs #tregulatorycells #circadianrhythm #circadian #circadianimpact #tregsandt1d #tcell #tcells

In this episode, Joanne Boldison discusses Role of immune B cells in the inflammatory T1D process.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #bcells #inflammatory #immunesystem #roleofbcells

In this episode, Lauren Quinn discusses Screening children for type 1 diabetes – the ELSA study.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #ELSA #ELSAstudy #screening #screenfort1d

In this episode, Vikash Chandra discusses candidate genes to drug target for type 1 diabetes.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #drugs #drugtarget #drug #candidategenes #targett1d

In this episode, Ulf Hannelius discusses Decoding the Future: Leveraging Biomarkers in Antigen-Specific Immunotherapy for Type 1 Diabetes.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #biomarkers #diamydmedical #diamyd #antigenspecific #immunotherapy #antigenspecificimmunotherapy #immunotherapyfort1d #immunotherapyfortype1diabetes #t1dbiomarkers #antigens

Listen to a sneak peek of podcast episode 50 with Ed Boyden at MIT. Hear what he has to say about how spatial multiplexing of fluorescent reporters for imaging signaling network dynamics can help researchers studying type 1 diabetes.

Follow the link below for full podcast episode:
https://www.podbean.com/eu/pb-igyzb-f7fc44

In this episode, Raghu Mirmira & Bobbie Jo Webb Robertson discuss Predicting New-Onset Type 1 Diabetes using Altered Pre-mRNA Splicing Events.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #newonsett1d #premrna #mrnasplicing #alteredpremrnasplicing

In this episode, Jean Claude Katte discusses specificities of type 1 diabetes in sub-Saharan Africa.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #africa #subsaharanafrica

In this episode, Laura Jacobsen discusses Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #treatment #immunotherapy #immunotherapytrials #clinicaltrials #treatmentefficacy #earlymetabolicendpoints

In this episode, Adrián Villalba Felipe discusses human pancreas development through 3D glasses.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #bioimaging #pancreas #pancreaticimaging #3D #humanpancreas

In this episode, Joana Almaça discusses pericytes and vascular control of islet function.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #pericytes #vascularcontrol #islet #isletfunction #pancreas

In this episode, Matthew Merrins PhD (UWisconsin Madison), Richard Kibbey MD PhD (Yale), Guy Rutter PhD (University of Montreal), and Ian Sweet PhD (UW Medicine Diabetes Inst) participate in a thoughtful discussion and respectful debate on: Glucose Regulation of β cells KATP Channels: Is a New Model Needed?

#novel #T1D #diabetes #type1diabetes #human #science #debate #scientficdebate #canonicalmodel #canonical #glucoseregulation #betacell #KATPchannels #newmodel

Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model! Diabetes, https://doi.org/10.2337/dbi23-0032

Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?https://doi.org/10.2337/dbi23-0031

Dr. Alok Joglekar joins us to discuss experimental and computational T cell antigen discovery in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Jack Virostko joins us to discuss imaging the pancreas in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Anath Shalev joins us to discuss more verapamil effects in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. James Heather joins us to discuss Stitchr, a tool for making and modifying T cell receptor sequences.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Emrah Altindis joins us to discuss how gut microbiota regulate pancreatic growth, exocrine function, and gut hormones.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Stephen Gray joins us to discuss the potential of blockchain technology for rewarding scientists and regenerative medicine metaverse.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Nayara Leite joins us again to discuss what's new with her research at Vertex Pharmaceuticals.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Alex Abramson joins us to discuss oral delivery of insulin and other macromolecule therapeutics using self-orienting pills.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Braulio Marfil-Garza and Dr. James Shapiro join us to discuss pancreatic islet transplantation in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Neil McKenna joins us to discuss transcriptional regulatory networks of circulating immune cells in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Abhishek Kulkarni joins us to discuss 12-LOX, a critical enzyme in the initiation and progression of T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Alma-Martina Cepika joins us to discuss antigen-specific type 1 regulatory T cells, including their mechanism of function and therapeutic use.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Tarin Bigley joins us to discuss neonatal roseolovirus infection inducing the disruption of thymic tolerance, resulting in autoimmunity and autoantibodies.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Julia Panzer and Dr. Alejandro Caicedo join us to discuss the targeting of pancreatic alpha-cells to prevent hypoglycemia in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Ping (Peter) Wang joins us to discuss the trends of nanotechnology in type 1 diabetes treatment.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

PhD candidate Teresa De Toni joins us to discuss parallel evaluation of polyethylene glycol conformal coating and alginate microencapsulation as immuno-isolation strategies for pancreatic islet transplantation.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Drs. Bobbie-Jo Webb-Robertson and Briggitte Frohnert join us to discuss machine learning integration for outcomes of type 1 diabetes.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Andres Garcia joins us to discuss biomaterials for the transplantation of insulin-producing cells.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Drs. Alice Carr and Sarah Richardson join us to discuss circulating C-peptides in children and young people, and pancreatic beta-cell loss in pancreas donors across T1D duration.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Remi Creusot joins us to discuss epitope-based tolerance-inducing immunotherapy for type 1 diabetes.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Kalpana Mandal joins us to discuss oxygen-generating microparticles for ischemic injury.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Drs. Gayle Boxx and Jan Mrazek join us to discuss how vaults intersect with autoimmunity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Elad Sintov joins us from the Melton Lab at Harvard to discuss deciphering the immunogenicity of stem cell-derived islets and ways to dampen it.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. William Rust joins us to discuss lab-grown islets for islet replacement therapy in the clinic.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Richard Benninger from the Barbara Davis Center at CU joins us to discuss the question, "Is there a pulsatile pacemaker in islet cells?"

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Emma Hamilton-Williams joins us to discuss targeting the gut microbiota as a new therapy for T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Amparo Guemes Gonzalez joins us to discuss bioelectric medicine and bringing the innovation to treating T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Andrea Schietinger joins us to discuss an autoimmune stem-like CD8 T-cell population and how it drives T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Tanmay Mathur and Abhishek Jain join us to discuss engineering diabetes with personalized and vascularized organ-chips.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Drs. Frances Ashcroft and Barbara Corkey join us to discuss the new paper, "Metabolic Cycles and Signals for Insulin Secretion". The paper challenges a key aspect of the "canonical" model.

Arthur D. Riggs, Ph.D., the world-renowned diabetes expert who developed the technology that led to the first human synthetic insulin for the treatment of diabetes, died March 23 after battling cancer. A biotechnology pioneer and a longtime leader at City of Hope, Riggs’ major scientific discoveries were achieved over more than a half-century of research, paving the way for development of the monoclonal antibody therapies that are the foundation of modern treatments for cancer, autoimmune diseases, blindness and a host of other diseases.

His breakthrough work in diabetes enabled mass production of insulin for people living with the disease. Today, synthetic insulin is used by hundreds of millions of people.

He was 82.

More details about his incredible scientific contributions and life can be found below and here:
https://www.cityofhope.org/breakthroughs/art-riggs-tribute

Speakers:
Debbie Thurmond, Ph.D., director, Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope
Fouad Kandeel, M.D., Ph.D., chair of Translational Research and Cellular Therapeutics, AR-DMRI, City of Hope
Anna Wu, Ph.D., chair, Department of Immunology & Theranostics, City of Hope
Stephen J. Forman, M.D., director, Hematologic Malignancies Research Institute, City of Hope
Rama Natarajan, Ph.D., chair, Department of Diabetes Complications & Metabolism, City of Hope
Jack Shively, Ph.D., professor, Department of Immunology & Theranostics, City of Hope
David Horne, Ph.D., vice provost and deputy director, Beckman Research Institute, City of Hope

Dr. Ulf Hannelius, CEO of Diamyd, joins us to discuss the company and the opportunity of GAD vaccination.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Barbara Corkey joins us to discuss induction of autoimmunity in T1D with a lipid focus.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Drs. Sara Tersey and Raghu Mirmira from the University of Chicago join us to discuss proinflammatory signaling in beta cells that trigger islet autoimmunity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Shmuel Levit joins us to discuss T1D remission and beta-cell regeneration, induced by oral administration of DDP-4 inhibitor, PPI and GABA in NOD mice and human patients.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Chenqu Suo joins us to discuss mapping the developing human immune system across organs.

Dr. Rohit Kulkarni joins us to discuss cross-talk between pancreatic endocrine and exocrine cells to decipher type 1 diabetes.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Speakers:
Dr. Camilo Ricordi, University of Miami
Dr. Piotr Witkowski, University of Chicago
Dr. Steven Paraskevas, McGill University
Dr. Peter Senior, University of Alberta

Dr. Lorenzo Pasquali joins us from Pomepeu Fabra University in Barcelona to discuss beta cell noncoding regulatory functions and T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

In this episode, Elliott Brooks discusses KLF4 and NKX2.2 cooperate to regulate pancreatic alpha cells.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #KLF4 #NKX2 #pancreas #alphacells #pancreaticalphacells #endocrine

In this episode, Kaiyven Efi Leslie discusses from anti-inflammatory cytokine IL13 to therapeutic targets of type 1 diabetes.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #therapy #therapeutics #diabetestherapeutics #antiinflammatory #inflammation #IL13

In this episode, Farooq Syed and Preethi Krishnan discusses β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #betacells #pathogenesis #diabetespathogenesis #microRNA #miRNA #molecularhub #biomarkers #diabetesbiomarkers

In this episode, Federica Vecchio discusses Investigating the impact of Coxsackievirus infection on β cells and the corresponding anti-viral CD8+ T-cell response.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #betacells #betacell #pancreas #coxsackievirus #cd8tcells #adaptiveimmunity #antiviral #tcell

In this episode, Aaron Cox discusses New leptin signaling mechanisms regulating islet function: Implications for T1D.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #islet #pancreas #leptin

In this episode, Hualin Zhou discusses A Novel Nitrosylase Prevents Hypoglycemia and Mediates Insulin Resistance.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #Novel #Nitrosylase #Hypoglycemia #Insulin #insulinresistance

In this episode, Jay Sosenko discusses Metabolic Endpoints for Type 1 Diabetes Prevention Trials Are Not as Simple as They Seem.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #metabolics #metabolism #endpoints #diabetesprevention #preventiontrials #trials

In this episode, Soumyadeep Sarkar discusses Regulation of Beta-cell Death by ADP Ribosylhydrolase ARH3 via Lipid Signaling in Insulitis.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #ADP #ADPribosylhydrolase #ARH3 #lipidsignaling #insulitis #betacelldeath #betacells

In this episode, Jeffrey Millman discusses Unraveling Cellular Complexity in Stem Cell-Derived Islet Identity through Single-Cell Sequencing.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #singlecellsequence #cellularcomplexity #stemcells #stemcellderived #stemcellislet #stemcellresearch

In this episode, Hannah Pizzato discusses Engineering Human Pluripotent Stem Cells to Evade Immunological Rejection.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #pluripotent #humanpluripotent #engineering #protocol #immunologicalrejection #stemcells #pluripotentstemcells #evade

In this episode, Dario De Jesus discusses m6A mRNA Methylation: A β-Cell Safeguard Mechanism Controlling the Innate Immune Responses in Type 1 Diabetes.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #harvard #betacells #innateimmunity #innateimmunesystem #controllinnateimmunesystem

In this episode, Will Rust discusses clinic-ready replacement pancreatic islets for insulin-requiring diabetes.

#novel #asktheexpert #ATE #T1D #seraxis #pancreaticislets #pancreaticisletreplacement #insulinrequiring #diabetes #type1diabetes #clinic #clinicalready #human #science

In this episode, Michael Snyder discusses Disrupting healthcare using deep data and remote monitoring.

#novel #asktheexpert #ATE #T1D #bioinformatics #deepdata #remotemonitoring #T2D #human #science

In this episode, Francisco Leon and Holger Russ discuss Translating Thymus Science to Potential Immune Tolerance Therapeutics.

#thymus #tolerancebio #immunetolerance #immunesystem #therapeutics #thymusscience #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Han Zhu discusses human β-cells in the dish: A human model for β-cell development and disease.

#betacells #betacelldevelopment #betacelldisease #humanmodel #humanresearch #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Carolyn McGrail from the Gaulton Lab discusses Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes.

#HLA #haplotypes #riskprediction #geneticdiscovery #genetics #screening #highrisk #DR3 #DR4 #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Peter van Endert discusses Insulin-degrading enzyme links beta cell protein homeostasis and proliferation with autoimmune diabetes.

#enzyme #insulindegrading enzyme #betacellprotein #betacell #homeostasis #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Danny Chou discusses Developing New Insulin with Improved Properties.

#insulin #newinsulin #chemistry #improvedinsulin #betterinsulin #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Quin Xie discusses Immune responses to gut bacteria predict disease onset in a Type 1 Diabetes prevention trial.

#gut #immuneresponses #immunology #preventiontrial #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Juan Dominguez, Fahd Qadir, Mayur Doke, & Isabella Altilio, a PhD student in the lab, join us to discuss pancreatic regeneration at work: lessons from dynamic scRNA sequencing of live human pancreas slices.

#cellmetabolism #scRNA #sequencing #RNAseq #singlecell #singlecellRNA #pancreas #pancreaticregeneration #regeneration #livehumanpancreas #humanpancreas #livehumanpancreasslices #pancreasslices #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Romina Bevacqua discusses CRISPR Gene Editing in Primary Human Islet Organoids.

#organoids #CRISPR #geneediting #crisprgeneediting #primaryhumanisletorganoids #humanislets #islets #pancreas #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Monica Westley, PhD, catches up with Bruce Verchere, PhD, the winner of the 2023 Lifetime Achievement Award in Diabetes.

#Lifetimeachievementaward #diabetesaward #2023lifetimeachievement #diabetes #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Feyza Engin and Hugo Lee discuss the crosstalk between beta cell unfolded protein response and senescence in T1D.

#crosstalk #betacells #beta #betacell #pancreas #protein #unfoldedprotein #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode we talk to Schafer Boeder MD, UCSD, Charlotte Chen DO, CHAM, Jamie Felton MD, Indiana SOM, & Zoe Quandt MD, UCSF to hear an update from the First Cohort of National NIH K12 DiabDocs Program Scholars.

#diabdocsprogram #diabdocs #UCSD #CHAM #IndianaSOM #UCSF #NationalNIH #firstcohort #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Andrew Koutnik discusses Type-1 Diabetes & Nutrition: Current Developments & Research Gaps.

#nutrition #diabetesnutrition #researchgaps #currentdevelopments #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Ben Voight discusses human genetics approaches to identify variants and genes contributing to diabetes.

#genetics #GWAS #genes #diabetes #type2diabetes #variants #humangenetics #data #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Matthias Hebrok discusses new regulators of human beta cell function.

#betacell #humanbetacell #regulators #betacellfunction #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Cristina Nostro discusses building human islets from pluripotent stem cells.

#stemcells #pluripotent #pluripotentstemcells #humanislets #islets #buildinghumanislets #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Sergei Pustylnikov discusses autoimmunity applications of a new efficient method for generating the data on T cell antigen specificity and corresponding TCRs.

#TCR #tcellreceptor #tcell #Tcellantigen #antigen #100xbio #efficientmethod #data #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Dr. Matthew Becker discusses immune engineered extracellular vesicles as a cell-free therapy for type 1 diabetes.

#immune #immunesystem #immunoengineering #immuneengineering #extracellularvesicles #cellfreetherapy #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Drs. Rayhan Lal, Anna Gloyn, Ananta Addala, and Danny Chou discuss Closing the Equity Gap in Diabetes.

#equity #equitygaps #diabeteshealthcare #equitygap #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Melanie Shapiro discusses insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.

#Treg #Tregulatorycells #IL2 #cytokines #growthfactor1 #insulin #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Siddhartha Sharma discusses leveraging circulating, insulin specific CD4 T cells to measure autoimmunity in type 1 diabetes.

#insulinspecificTcells #CD4Tcells #autoimmunity #insulin #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Stephen (Steve) Parker discusses from diabetes genetic variant to single cell (state): what’s the context?

#singlecell #genetics #bioinformatics #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Izortze Santin Gomez discusses non-coding RNA-regulated pathways in pancreatic beta cells: their role in T1D development.

#RNA #noncodingRNA #pancreas #betacells #insulinproducingcell #t1ddevelopment #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Alexandra Coomans De Brachene discusses interferons are the key cytokines acting on pancreatic islets in type 1 diabetes.

#cytokines #pancreaticislets #islets #interferons #pancreas #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Drs. Karen Guillemin and Jennifer Hill discuss poking at the pancreas: effects of a microbiota protein on beta cell proliferation.

#betacell #betacellproliferation #microbiota #microbiotaprotein #gut #pancreas #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Drs. Rachel Bonami and Dudley McNitt discuss sneaking past the bouncer: how anti-insulin B lymphocytes break into germinal center clubs.

#germinalcenters #lymphocytegeneration #bcells #lymphocytes #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Sangeeta Dhawan discusses Beta cell identity: from development to diabetes.

#betacell #development #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Drs. Laura Elo and Riitta Lahesmaa discuss markers associated with progression of type 1 diabetes.

#markers #t1dprogression #t1dmarkers #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Josh Doloff discuss Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles.

#islet #engrafts #immunomodulation #tolerogenicmicroparticles #microparticles #polymers #Tregs #islettransplant #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Dr. Abhijeet Patil discuss Modeling Type 1 Diabetes Progression from Single-cell Transcriptomic Measurements in Human Islets.

#transcriptome #singlecell #humanislet #islets #modelling #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Stephanie Hanna discusses intradermal injection of diabetes autoantigens results in recruitment of clonally expanded antigen specific T cells to skin and draining lymph nodes and facilitates monitoring of autoimmune response.

#novel #asktheexpert #ATE #T1D #intradermal #autoantigens #autoimmunity #Tcells #TCR #autoimmuneresponse #autoimmunediseases #therapeutics #science

In this episode, Irina Buckle discusses RAGE targeting therapeutics in T1D.

#novel #asktheexpert #ATE #T1D #RAGE #teplizumab #therapy #therapeutics #science #drug

In this episode, Matthew Wortham discusses epigenomic control of cell state in β-cell adaptation and failure.

#novel #asktheexpert #ATE #T1D #betacell #epigenetics #adapt #failure #science

In this episode, Helena Oakey and Ki Wook-Kim discuss protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity (ENDIA) cohort.

#novel #asktheexpert #ATE #T1D #statistician #statistics #ENDIA #humanstudy #autoimmunity #omics #human #science

In this episode, Erez Dror discusses how leveraging epigenetic heterogeneity resulted in the identification of two major β cell subsets.

#novel #asktheexpert #ATE #T1D #betacell #epigenetics #heterogeneity #human #science

In this episode, Geming Lu, Randy Kang, and Adolfo Garcia-Ocana discuss Single Nucleus RNA Sequencing Analysis Reveals Novel Insights in the Human Islet Transcriptome.

#snRNA #singlenucleusRNA #sequencing #RNAseq #RNAsequencing #RNA #novel #asktheexpert #ATE #T1D #islet #transcriptome #datasharing #humanislet #human #science

In this episode, Drs. Jing Hughes and Ben Giepmans join us to discuss advances in islet SEM: scanning below the membrane.

#SEM #islet #membrane #electronmicroscopy #cilia #advancingscience #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

Sonja Schrepfer joins us to discuss translating discoveries: engineering of allogeneic donor cells for acceptance by the host's immune system.

#type1diabetes #t1d #allogeneic #engineering #immunesystem #science #asktheexpert #asktheexperts

Francois Pattou joins us to discuss association between primary graft function and 5-year outcomes of islet allogenic transplantation in Type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry.

We apologize that some of the audio quality is poor near the middle and end time points.

#type1diabetes #t1d #5yearstudy #islet #allogenic #transplantation #primarygraft #observationalstudy #islettransplantregistry #science #asktheexpert #asktheexperts

In this episode, Drs. Joe Qiao Zhou and Lauretta Lacko introduce the HUMAN THERAPEUTIC ORGANOID CORE (HTOC) at Weill Cornell

#organoids #weillcornell #cornell #HTOC #stemcells #vertex #insulinorganoids #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

Stefan Ledinger joins us to discuss T1D as a complex metabolic disease: metabolomics as a tool to explore pathophysiology and enable personalized medicine.

#type1diabetes #t1d #metabolomics #biocrates #pathophysiology #personalizedmedicine #science #asktheexpert #asktheexperts

Daniel Espes joins us to discuss classifying hypoglycemic events with machine learning algorithms.

#type1diabetes #t1d #algorithm #machinelearning #hypoglycemia #science #asktheexpert #asktheexperts

Holger Russ joins us to discuss generation of functional thymic organoids from human pluripotent stem cells.

#type1diabetes #t1d #stemcells #pluripotent #thymicorganoids #organoids #humanstudies #science #asktheexpert #asktheexperts

In this episode, Drs. Joe Qiao Zhou and Steve Xiaofeng Huang discuss their talk Restoring Glucose Homeostasis with Stomach-derived human insulin-secreting organoids.

#organoids #homeostasis #glucose #glucosecontrol #stemcells #stomach #insulinorganoids #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

Eric Chang joins us to discuss making brain-body and neuro-immune connections with the vagus nerve.

#type1diabetes #t1d #vagusnerve #brain #braidbody #neuroimmune #neuroscience #science #asktheexpert #asktheexperts

In this episode, Drs. Olga Gornik and Najda Rudman discuss their talk N-glycosylation and its genetic regulation in type 1 diabetes, Sweet solution to diabetes?

#NGlycosylation #glycans #solution #genetics #geneticregulation #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

Caroline Miranda and Haiqiang Dou discuss disturbance of cell-cell crosstalk in type 1 diabetes.

#type1diabetes #t1d #cell #crosstalk #cellcrosstalk #novel #science #asktheexpert #asktheexperts

Gladys Teitelman joins us to discuss the human beta cell: victim or instigator of Type 1 Diabetes development?

#Pax5 #type1diabetes #t1d #betacell #islet #novel #science #asktheexpert #asktheexperts

Karl Bacos joins us to discuss PAX5 - a new player in T2D pathophysiology.

#Pax5 #type2diabetes #pathophysiology #novel #science #asktheexpert #asktheexperts

Billur Akkaya joins us to discuss deciphering the specificity and molecular mechanisms of regulatory T cells using novel approaches.

#Tcells #type1diabetes #t1d #Tregs #Tregulatorycells #specificity #molecularmechanisms #novel #science #asktheexpert #asktheexperts

Antonio Citro joins us to discuss directed self assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes. Due to some technical difficulties, there are a few glitches at the end.

#type1diabetes #t1d #pancreas #endocrinology #endocrinepancreas #xenogenic #xenogenicpancreas #treatment #science #asktheexpert #asktheexperts

Josephine Forbes and Sherman Leung join us to discuss all the RAGE….A novel target for prevention of type 1 diabetes.

#type1diabetes #t1d #RAGE #noveltarget #prevention #treatment #science #asktheexpert #asktheexperts

Laura Jacobsen joins us to discuss the Emerging Biomarkers of Response to Immunotherapies.

#biomarkers #type1diabetes #t1d #immunotherapy #physicianscientist

Mohsen Khosravi Maharlooei joins us to discuss the role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.

#type1diabetes #autoimmune #humanimmunesystem #humanizedmice #thymus

Ruth Elgamal from the Kyle Gaulton lab at UCSD joins us to discuss an integrated pancreatic islet reference map: creating accessible tools and resources.

Drs. Martin Hessner and Pinar Sargin join us to discuss L. plantarum probiotic supplementation and diet – synergistic effect in T1D prevention in rats.

#T1D #type1diabetes #probiotics #diet #LPlantarum

Drs. Mia Øgaard Mønsted and Martin Haupt-Jorgensen from Bartholin Institute join us to discuss the role of the intestine in the development of T1D.

#intestine #type1diabetes #bartholininstitute #trainee #development #endocrinology #gut

Dr. Klaus Kaestner joins us to discuss the Human Pancreas Analysis Program and enabling new insights into type 1 diabetes.


#HPAP #pancreas #pancreatic #analysis #type1diabetes #upenn

Dr. Hashem Koohy joins us from the University of Oxford to discuss the computational and machine-learning prediction of CD8 T cells’ target.


#Oxford #CD8 #Tcells #type1diabetes #computational #machinelearning #CD8target

Dr. Lulu Jiang from Boston University joins us to discuss stress granules and their connections to neurodegeneration.

#multidisciplinary #t1d #type1diabetes #research #neurodegeneration #neuroscience #stressgranules

Dr. Alberto Pugliese from City of Hope joins us to discuss new leadership in Type 1 Diabetes Research at City of Hope.

Dr. Esteban Gurzov from Université Libre de Bruxelles joins us to discuss fixing dysfunctional signaling in type 1 diabetes, are we on the right track or a lost cause?

Dr. Francois Moreau from Joslin Diabetes Center joins us to discuss unique interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.

Dr. Kevan Herold and Dr. Matthias Von Herrath from Yale and UCSD respectively join us to discuss opportunities for Teplizumab in the treatment of Type 1 diabetes.

#Teplizumab

Dr. Xiaoyan Yi from ULB center for diabetes research joins us to discuss mining the transcriptome of target tissues of autoimmune and degenerative pancreatic beta-cell and brain diseases to discover therapies.

Dr. Heather Denroche from UBC joins us to discuss islet amyloid in type 1 diabetes: a paradox in immune-mediated beta-cell loss.

Dr. Per-Ola Carlsson from NextCell Pharma joins us to discuss mesenchymal stromal cells to intervene in the development of type 1 diabetes.

Dr. Chih-Wei Logan Hsu from Baylor College joins us to discuss EZ Clear for simple, rapid, and robust mouse whole organ clearing.

Dr. Slavica Tudzarova from UCLA joins us to discuss the beta-cell uphill battle in type 1 diabetes.

Carolyn McGrail PhD candidate at the Dr. Kyle Gaulton lab joins us to discuss fine-mapping Type 1 Diabetes risk variants in the MHC.

Dr. Ed Phelps from University of Florida joins us to discuss pancreas slices to study interactions between immune cells and islets.

Dr. Eddie James from the Benaroya Research Institute joins us to discuss applying in depth studies of beta cell specific T cells to understand disease progression and response to therapy.

Drs. Chris Fraker and Allison Bayer from the DRIF join us to discuss the role of Natural Killer (NK) cells in context of Type 1 Diabetes.

Dr. Jaume joins us to discuss the homing of Antigen-Specific CAR T Regulatory Cells to Human Pancreatic Islets and Pre-clinical Type 1 Diabetes Reversal.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Chantal Mathieu joins us to discuss the mission of INNODIA.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/