Single Cell Sequencing in T1D

Dr. Kyle Gaulton joins us to discuss interpreting type 1 diabetes risk with genetics and single cell epigenetics.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Chenqu Suo joins us to discuss mapping the developing human immune system across organs.

Dr. Elad Sintov joins us from the Melton Lab at Harvard to discuss deciphering the immunogenicity of stem cell-derived islets and ways to dampen it.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

In this episode, Juan Dominguez, Fahd Qadir, Mayur Doke, & Isabella Altilio, a PhD student in the lab, join us to discuss pancreatic regeneration at work: lessons from dynamic scRNA sequencing of live human pancreas slices.

#cellmetabolism #scRNA #sequencing #RNAseq #singlecell #singlecellRNA #pancreas #pancreaticregeneration #regeneration #livehumanpancreas #humanpancreas #livehumanpancreasslices #pancreasslices #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

Dr. Jennifer Wang and Dr. Decio Eizirik join us to discuss T1 interferons and autoimmune diseases.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

In this episode, Stephanie Hanna discusses intradermal injection of diabetes autoantigens results in recruitment of clonally expanded antigen specific T cells to skin and draining lymph nodes and facilitates monitoring of autoimmune response.

#novel #asktheexpert #ATE #T1D #intradermal #autoantigens #autoimmunity #Tcells #TCR #autoimmuneresponse #autoimmunediseases #therapeutics #science

Drs. Sara Tersey and Raghu Mirmira from the University of Chicago join us to discuss proinflammatory signaling in beta cells that trigger islet autoimmunity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

In this episode, Jeffrey Millman discusses identification of unique cell type responses in pancreatic islets to stress.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #pancreaticislets #islets #isletstress #uniquecelltype #cells #pancreas

In this episode, Tarun Pant discusses monocyte populations in type 1 diabetes families exhibit high activity and subset abundances that correlation with clinical progression

In this episode, Rene van Tienhoven joins us to discuss genetic beta cell protection by nature.

In this episode, Anshul Kundaje joins us to discuss disease diagnostics using machine learning of B cell and T cell receptor sequences.

In this episode, Nathan Steenbuck PhD Candidate in the Bodenmiller Laboratory discusses imaging mass cytometry reveals early beta-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata.

In this episode, Kagan Karakus joins us to discuss T-cell receptor sequences targeting beta-cell proteins present in blood across stages of type 1 diabetes development.

In this episode, Eugenia Vazquez & Decio Eizirik join us to discuss Differential Immune & Apoptosis-Related Gene Signatures in Pancreatic Alpha & Beta Cells Contribute to their Fate in Type 1 Diabetes.

In this episode, Lukas Oesinghaus joins us to discuss decoding human immune states using high-throughput perturbation screens: a single cell cytokine dictionary of human peripheral blood.

In this episode, Izorte Santin Gomez, PhD, and Eddie James, PhD, join us to discuss long non-coding RNAs as a novel source of beta cell autoantigens in type 1 diabetes.

In this episode, Maki Nakayama, MD, joins us to discuss Quantitative V-gene-targeted T cell Receptor Sequencing as a Biomarker in Type 1 Diabetes.