“-omics” Studies of T1D

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In this episode, Xiaoyan and Priscila join us to discuss transcriptomics of autoimmune disease identifies FGFR1 as a target for pancreatic beta-cell protection.

In this episode, Shuibing Chen & Stephen Parker join us to discuss Integrative single-cell multi-omics profiling of human pancreatic islets identifies TID-associated genes and regulatory signals.

In this episode, Karoliina Hirvonen joins us to discuss proteomics insights into type 1 diabetes development.

In this episode, Robert Moulder joins us to discuss targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease.

#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #type1diabetesresearch #serum #serumproteomics #proteomics #science #markers #t1dmarkers #biomarkers #newlydiagnosed #youth

In this episode, Erica Cai joins us to discuss genome-wide in vivo CRISPR screen uncovers ZBED3 as a transcriptional regulator of beta cell vulnerability in type 1 diabetes.


#type1diabetes #type1diabetesresearch #t1d #CRISPR #CRISPRscreen #betacell #betacellvulnerability #transcriptionalregulator #genomewidescreen #invivo #ZBED3

In this episode, Alessandra Petrelli discusses a multi-omics integration approach relying on circulating factors does not discern endotypes in childhood type 1 diabetes.

#asktheexpert #ATE #endotypes #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #childhooddiabetes #omics #multiomics #t1dendotypes

In this State of the Science discussion, Jelena Colic and Haoning Howard discuss: Human Islets Case Study #1: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease.

#SOS #SOS2024 #diabetesresearch #diabetes #t1d #type1diabetes #scientifictool #humanislets #casestudy #islets #pancreas #proteomics #insulinsecretion #healthanddisease

In this episode, Abhijeet Patil PhD discusses Modeling Type 1 Diabetes Progression using Machine-learning and Single-cell Transcriptomic Measurements in Human Islets.

In this episode, Jeffrey Millman discusses Unraveling Cellular Complexity in Stem Cell-Derived Islet Identity through Single-Cell Sequencing.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #singlecellsequence #cellularcomplexity #stemcells #stemcellderived #stemcellislet #stemcellresearch

In this episode, Carolyn McGrail from the Gaulton Lab discusses Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes.

#HLA #haplotypes #riskprediction #geneticdiscovery #genetics #screening #highrisk #DR3 #DR4 #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Ben Voight discusses human genetics approaches to identify variants and genes contributing to diabetes.

#genetics #GWAS #genes #diabetes #type2diabetes #variants #humangenetics #data #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Stephanie Hanna discusses intradermal injection of diabetes autoantigens results in recruitment of clonally expanded antigen specific T cells to skin and draining lymph nodes and facilitates monitoring of autoimmune response.

#novel #asktheexpert #ATE #T1D #intradermal #autoantigens #autoimmunity #Tcells #TCR #autoimmuneresponse #autoimmunediseases #therapeutics #science

In this episode, Helena Oakey and Ki Wook-Kim discuss protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity (ENDIA) cohort.

#novel #asktheexpert #ATE #T1D #statistician #statistics #ENDIA #humanstudy #autoimmunity #omics #human #science

Ruth Elgamal from the Kyle Gaulton lab at UCSD joins us to discuss an integrated pancreatic islet reference map: creating accessible tools and resources.

Dr. Xiaoyan Yi from ULB center for diabetes research joins us to discuss mining the transcriptome of target tissues of autoimmune and degenerative pancreatic beta-cell and brain diseases to discover therapies.

Drs. Sara Tersey and Raghu Mirmira from the University of Chicago join us to discuss proinflammatory signaling in beta cells that trigger islet autoimmunity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Chenqu Suo joins us to discuss mapping the developing human immune system across organs.

Dr. Elad Sintov joins us from the Melton Lab at Harvard to discuss deciphering the immunogenicity of stem cell-derived islets and ways to dampen it.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Drs. Bobbie-Jo Webb-Robertson and Briggitte Frohnert join us to discuss machine learning integration for outcomes of type 1 diabetes.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/