Novel Techniques in T1D Research

In this episode, Ulf Ahlgren joins us to discuss Islet Cellularity in Health and Type 1 Diabetes: insights from deep tissue 3D imaging.

In this episode, Michel Edwar Mickael joins us to discuss the search for diabetes-specific t-cell repertoires.

In this episode, Chandrabali Bhattacharya joins us to discuss endogenous targeting lipid nanoparticles (ENDO) platform for systemic delivery of mRNA to pancreas.

In this episode, Eric Chang joins us to discuss making brain-body and neuron-immune connections with the vagus nerve.

In this episode, Samuel Canner a PhD candidate in Jeffrey Gray Lab at Johns Hopkins joins us to discuss the proteome as a lectome: deep learning suggests substantial protein carbohydrate interplay.

#proteome #deeplearning #carbohydrate #carbohydrates #proteins #johnshopkins #diabetes #type1diabetes #diabetesresearch #novelscience #science #type1diabetesresearch

In this episode, Antonio Citro joins us to discuss bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes.

In this episode, Brian Corrie joins us to discuss iReceptor and the Type 1 Diabetes AIRR Consortium.

#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #type1diabetesresearch #ireceptor #tcr #bcr #receptor #tcell #bcell #vdj #consortium #AIRR #repertoire #AdaptiveImmuneReceptorRepertoire #adaptiveimmunity

In this episode, Zachary Freyberg discusses Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #dopamine #newtools #peripheraldopamine #D2likereceptor #dopaminereceptor #dysglycemia #signaling

In this episode, Matthew Merrins from University of Wisconsin-Madison and Richard Benninger from University of Colorado discuss 3D light-sheet imaging of the islet: New insights into the beta cell subpopulations that lead and coordinate Ca2+ oscillations.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #betacells #3dlightimaging #pancreas #pancreaticimaging #calcium #calciumoscillations #betacellsubpopulations

In this episode, Abhijeet Patil PhD discusses Modeling Type 1 Diabetes Progression using Machine-learning and Single-cell Transcriptomic Measurements in Human Islets.

One hour panel discussion of new tool:
HumanIslets: An integrated platform for human islet data access and analysis

Included the following scientists:
Jessica Ewald, PhD
Patrick MacDonald, PhD

In this episode, Sergei Pustylnikov discusses autoimmunity applications of a new efficient method for generating the data on T cell antigen specificity and corresponding TCRs.

#TCR #tcellreceptor #tcell #Tcellantigen #antigen #100xbio #efficientmethod #data #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Drs. Jing Hughes and Ben Giepmans join us to discuss advances in islet SEM: scanning below the membrane.

#SEM #islet #membrane #electronmicroscopy #cilia #advancingscience #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

In this episode, Drs. Joe Qiao Zhou and Lauretta Lacko introduce the HUMAN THERAPEUTIC ORGANOID CORE (HTOC) at Weill Cornell

#organoids #weillcornell #cornell #HTOC #stemcells #vertex #insulinorganoids #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

Ruth Elgamal from the Kyle Gaulton lab at UCSD joins us to discuss an integrated pancreatic islet reference map: creating accessible tools and resources.

Dr. Chih-Wei Logan Hsu from Baylor College joins us to discuss EZ Clear for simple, rapid, and robust mouse whole organ clearing.

Dr. Alex Abramson joins us to discuss oral delivery of insulin and other macromolecule therapeutics using self-orienting pills.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Alok Joglekar joins us to discuss experimental and computational T cell antigen discovery in T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Stephen Gray joins us to discuss the potential of blockchain technology for rewarding scientists and regenerative medicine metaverse.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. James Heather joins us to discuss Stitchr, a tool for making and modifying T cell receptor sequences.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/