Molecular Approaches in T1D Research

In this episode, Kathrin Maedler joins us to discuss does type 1 diabetes start in the exocrine pancreas?

#type1diabetes #diabetesscience #diabetes #diabetesresearch #type1diabetesresearch #universityofbremen #exocrine #exocrinepancreas #pancreas #pathophysiology

In this episode, Luc Teyton joins us to discuss how to understand the initiation of type 1 diabetes.

In this episode, Eric Chang joins us to discuss making brain-body and neuron-immune connections with the vagus nerve.

In this episode, Henrick Hill joins us to discuss GABA therapy in long-standing Type 1 Diabetes.

In this episode, Jon Mentxaka discusses LncRNA-deprived peptides as a new source of auto reactive T cell epitopes in type 1 diabetes.

In this episode, Raghu Mirmira and Sarah Tersey discuss 12-Lipoxygenase Inhibition delays autoimmune diabetes in human gene replacement mice.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #humangene #mice #micestudies #12LOX

In this episode, Andrea Annoni discusses gene transfer-based strategies for the induction of Ag-specific immune tolerance in Type 1 Diabetes.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #antigens #antigenspecifictherapy #immunetolerance #immunesystem #antigeninduction #genetherapies #genestrategies

In this episode, Farooq Syed and Preethi Krishnan discusses β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #betacells #pathogenesis #diabetespathogenesis #microRNA #miRNA #molecularhub #biomarkers #diabetesbiomarkers

In this episode, Juan Dominguez, Fahd Qadir, Mayur Doke, & Isabella Altilio, a PhD student in the lab, join us to discuss pancreatic regeneration at work: lessons from dynamic scRNA sequencing of live human pancreas slices.

#cellmetabolism #scRNA #sequencing #RNAseq #singlecell #singlecellRNA #pancreas #pancreaticregeneration #regeneration #livehumanpancreas #humanpancreas #livehumanpancreasslices #pancreasslices #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Irina Buckle discusses RAGE targeting therapeutics in T1D.

#novel #asktheexpert #ATE #T1D #RAGE #teplizumab #therapy #therapeutics #science #drug

Josephine Forbes and Sherman Leung join us to discuss all the RAGE….A novel target for prevention of type 1 diabetes.

#type1diabetes #t1d #RAGE #noveltarget #prevention #treatment #science #asktheexpert #asktheexperts

Dr. Lorenzo Pasquali joins us from Pomepeu Fabra University in Barcelona to discuss beta cell noncoding regulatory functions and T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Rob Screaton from the University of Toronto joins us to discuss whether we can get adult human beta cells to regenerate.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Jonathan Weissman joins us to discuss genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Professor Josephine Forbes discusses her work with the receptor sRAGE.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/