Insulin in T1D

In this episode, Kyle Apley joins us to discuss Developing Insulin Variants to Target Insulin-Binding B cells in T1D.

Fatoumata Samassa (Fatoumata.samassa@inserm.fr): IFN-alpha promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic beta-cells

Clémentine Halliez (clementine.halliez@inserm.fr): T-cell killing assays to model beta-cell vulnerability/resistance in vitro.

Widad Nefida (widad.nefida@inserm.fr): insulin allergy as a model condition to test tolerogenic therapies prior to T1D prevention studies.

In this State of the Science discussion, Jelena Colic and Haoning Howard discuss: Human Islets Case Study #1: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease.

#SOS #SOS2024 #diabetesresearch #diabetes #t1d #type1diabetes #scientifictool #humanislets #casestudy #islets #pancreas #proteomics #insulinsecretion #healthanddisease

Dr. Anoop Arunagiri joins us to discuss the contributors to proinsulin misfolding in pancreatic beta cells!

#t1d #science #proinsulin #proinsulinmisfolding #proteinmisfolding #erstress #pancreas #betacells #transcription #translation

In this episode, Danny Chou discusses Developing New Insulin with Improved Properties.

#insulin #newinsulin #chemistry #improvedinsulin #betterinsulin #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

Dr. Alex Abramson joins us to discuss oral delivery of insulin and other macromolecule therapeutics using self-orienting pills.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Ester Caffarel-Salvador joins us to discuss oral insulin.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Maria Jose Redondo joins us to discuss what's new with TCG7L2 and insulin sensitivity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert