Immune Cells in T1D – thesugarscience

In this episode, Gabriela Ramirez-Hernandez joins us to discuss 1c Metabolisms in CD8 T cell responses during type 1 diabetes.

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T1D Th1nk Tank: Gabriela Ramirez-Hernandez, PhD, Harvard Broad Institute

The Sugar Science November 6, 2025 7:48 am

In this episode, Shani Peleg discusses RNA editing deficiency models differential immunogenicity of alpha and beta-cells.

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T1D Th1nk Tank: Shani Peleg, MD PhD Candidate, Hebrew University of Jerusalem

The Sugar Science August 23, 2025 4:23 am

In this episode, Leeana Peters joins us to discuss investigating tissue immune phenotype and receptor repertoire in type 1 diabetes.

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T1D Th1nk Tank: Leeana Peters, PhD, University of Florida

The Sugar Science July 29, 2025 6:47 am

In this episode, Kyle Apley joins us to discuss Developing Insulin Variants to Target Insulin-Binding B cells in T1D.

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T1D Th1nk Tank: Kyle Apley, PhD, WashU St. Louis

The Sugar Science July 29, 2025 6:33 am

In this episode, Matthew and Puchong discuss alpha-CD226 suppresses diabetes development in the NOD Mouse by augmenting Tregs and diminishing effector T cell function.

#type1diabetes #type1diabetesresearch #t1d #novel #science #diabetesresearch #research #researchtalk #alphacd226 #cd226 #NODmouse #tregs #effectortcells

In this episode, Matthew and Puchong discuss alpha-CD226 suppresses diabetes development in the NOD Mouse by augmenting Treds and diminishing effector T cell function.

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T1D Th1nk Tank: Matthew Brown, BS and Puchong Thirawatananond, MD PhD

The Sugar Science March 15, 2025 5:55 pm

In this episode, Jamie Felton joins us to discussing betting on the B team: a case for targeting B cells in type 1 diabetes progression.

#type1diabetes #type1diabetesresearch #t1d #Bcells #diseaseprogression #targetingbcells #diabetesprogression

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Indiana University Site Visit - Jamie Felton, MD

The Sugar Science February 5, 2025 4:45 pm

In this episode, Puneet Rawat discusses Understanding the role of T-cell receptor repertoire in T1D status.

T1D Th1nk Tank is discussions to fuel novel hypotheses, protocols and collaboration in T1D Research.

#type1diabetes #type1diabetesresearch #t1d #novel #science #TCR #Tcellreceptor #repertoire #TCRrepertoire

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T1D Th1nk Tank: Puneet Rawat, PhD, University of Oslo

The Sugar Science January 22, 2025 11:10 am

In this episode, Mai Tran discusses Mechanism for cross-reactivity of T cell receptors with InsC-peptide and hybrid insulin peptides presented by HLA-DQ8.

#type1diabetes #type1diabetesresearch #t1d #novel #science #insulinpeptide #peptide #DQ8 #haplotype #HLA #TCR #Tcellreceptor #crossreactivity

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Ask the Expert: Mai Tran, PhD, Monash Institute

The Sugar Science January 22, 2025 9:36 am

In this episode, Jon Mentxaka discusses LncRNA-deprived peptides as a new source of auto reactive T cell epitopes in type 1 diabetes.

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Ask the Expert: Jon Mentxaka Salgado, MS PhD Candidate, University of Basque County

The Sugar Science December 17, 2024 9:12 am

In this episode, Paul Thomas discusses T cell receptor pipelines for type 1 diabetes.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #tcrbeta #tcr #tcellreceptor #tcells #repertoire #TCR #pipeline

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Ask the Expert: Paul Thomas, PhD, St. Jude Children's Memphis

The Sugar Science November 19, 2024 12:32 pm

In this episode, Peter Linsley discusses alpha-centric TCRs in Type 1 Diabetes

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Ask the Expert: Peter Linsley, PhD, Benaroya Research Institute

The Sugar Science October 21, 2024 2:49 pm

In this episode, Tarun Pant discusses monocyte populations in type 1 diabetes families exhibit high activity and subset abundances that correlation with clinical progression

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Ask the Expert: Tarun Pant, PhD, the Medical College of Wisconsin

The Sugar Science September 21, 2024 4:16 pm

Join us as Dr. Oliver Harrison discusses tracking immunity to gut microbes!

#science #guthealth #microbiome #microbiology #type1diabetes #immunity #immunology #immunehealth

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Ask the Expert: Oliver Harrison, PhD, Benaroya Research Institute

The Sugar Science August 23, 2024 5:35 pm

In this episode, Alok Joglekar PhD discusses Dissecting the autoimmune repertoires in Type 1 Diabetes.

#autoimmune #t1d ##novel #science #noveldrug #thesugarscience #biomedicalsciences #immunology #tcells #TCRs #computationalbiology #systemsbiology #antigen #human #Universityofpittsburg

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Ask The Expert: Alok Joglekar, PhD, University of Pittsburgh

The Sugar Science August 20, 2024 11:00 am

Dr. Maria Ruiz joins us to discuss predictive signatures of HLA types from T-cell repertoires.

#asktheexpert #t1d #HLAtypes #immunology #tcell #immuneresponse #MHCrestriction #tcrs #novel #science

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Ask the Expert: Maria Ruiz, PhD, Mt. Sinai Hospital, NYC

The Sugar Science August 15, 2024 8:17 pm

In this episode, David Perna-Barrull discusses Unveiling the Immune Dance: Macrophages role in Type 1 Diabetes immunotherapy.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #immunotherapy #macrophages #immunedance #macrophage #innateimmunity #monocytes #unveil

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Ask the Expert: David Perna-Barrull, PhD, Institut de Recerca Germans Trias i Pujol

The Sugar Science July 2, 2024 1:10 pm

In this episode, Joanne Boldison discusses Role of immune B cells in the inflammatory T1D process.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #bcells #inflammatory #immunesystem #roleofbcells

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Ask the Expert: Joanne Boldison, PhD, Exeter Medical School

The Sugar Science June 25, 2024 12:19 pm

In this episode we talk to Schafer Boeder MD, UCSD, Charlotte Chen DO, CHAM, Jamie Felton MD, Indiana SOM, & Zoe Quandt MD, UCSF to hear an update from the First Cohort of National NIH K12 DiabDocs Program Scholars.

#diabdocsprogram #diabdocs #UCSD #CHAM #IndianaSOM #UCSF #NationalNIH #firstcohort #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

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Ask the Expert: An Update from the First Cohort of National NIH K12 DiabDocs Program Scholars

The Sugar Science December 20, 2023 4:15 pm

In this episode, Sergei Pustylnikov discusses autoimmunity applications of a new efficient method for generating the data on T cell antigen specificity and corresponding TCRs.

#TCR #tcellreceptor #tcell #Tcellantigen #antigen #100xbio #efficientmethod #data #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

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Ask the Expert: Sergei Pustylnikov, PhD and CEO, 100XBio

The Sugar Science December 19, 2023 1:24 pm

In this episode, Dr. Josh Doloff discuss Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles.

#islet #engrafts #immunomodulation #tolerogenicmicroparticles #microparticles #polymers #Tregs #islettransplant #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

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Ask the Expert: Josh Doloff, PhD, Johns Hopkins School of Medicine

The Sugar Science September 22, 2023 5:03 pm