Biomarkers of T1D

In this episode, Nathan Steenbuck PhD Candidate in the Bodenmiller Laboratory discusses imaging mass cytometry reveals early beta-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata.

In this episode, Robert Moulder joins us to discuss targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease.

#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #type1diabetesresearch #serum #serumproteomics #proteomics #science #markers #t1dmarkers #biomarkers #newlydiagnosed #youth

At this remote site visit with Indiana University SOM we discuss Type 1 Diabetes Moonshot at IU including discussions about pathology, biomarkers, and clinical translation.

#type1diabetes #type1diabetesresearch #mRNA #riskmarkers #riskscore #biomarkers #HLA #haplotypes #diabetesrisk #diabetesriskscore

In this episode, Anand Hardikar discusses development of a microRNA-based Dynamic Risk Score for T1D.

T1D Th1nk Tank is discussions to fuel novel hypotheses, protocols and collaboration in T1D Research.

#type1diabetes #type1diabetesresearch #t1d #novel #science #miRNA #microRNA #riskscore #t1drisk #t1driskscore #biomarkers

In this episode, Emmanuel Bosi discusses the Italian law on screening for type 1 diabetes and celiac disease in the general pediatric population: an update fall 2024.

#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #italianlaw #screening #celiacdisease #generalpediatrics #fall2024

In this episode, multiple presenters join us to Experts Debate: Autoantibodies in T1D: Biomarkers or Mediators of Destruction?

Presenters:
Ake Lernmark, PhD
Eddie James, PhD
Chris Hampe, PhD
lan Sweet, PhD
Sally Kent, PhD

Join us for the site visit at Vanderbilt School of Medicine as we talk to:
Moderator: Al Powers, MD
Daniel Moore, MD PhD
Bill Russell, MD

In this episode, Alessandra Petrelli discusses a multi-omics integration approach relying on circulating factors does not discern endotypes in childhood type 1 diabetes.

#asktheexpert #ATE #endotypes #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #childhooddiabetes #omics #multiomics #t1dendotypes

In this episode, Abhijeet Patil PhD discusses Modeling Type 1 Diabetes Progression using Machine-learning and Single-cell Transcriptomic Measurements in Human Islets.

Dr. Maria Ruiz joins us to discuss predictive signatures of HLA types from T-cell repertoires.

#asktheexpert #t1d #HLAtypes #immunology #tcell #immuneresponse #MHCrestriction #tcrs #novel #science

In this episode, Inna Starskaia in the lab of Dr. Riitta Lahesmaa discusses distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #immuneresponse #autoantibodies @zntransporter #autoantibodiesinchildren #turku #TurkuBioscienceCentre

In this episode, Nick Thomas discusses Adult onset type 1 diabetes: Insights and unanswered questions.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #questions #unansweredquestions #adultonset #adultt1d #adultonsett1d

In this episode, Ulf Hannelius discusses Decoding the Future: Leveraging Biomarkers in Antigen-Specific Immunotherapy for Type 1 Diabetes.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #biomarkers #diamydmedical #diamyd #antigenspecific #immunotherapy #antigenspecificimmunotherapy #immunotherapyfort1d #immunotherapyfortype1diabetes #t1dbiomarkers #antigens

In this episode, Raghu Mirmira & Bobbie Jo Webb Robertson discuss Predicting New-Onset Type 1 Diabetes using Altered Pre-mRNA Splicing Events.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #newonsett1d #premrna #mrnasplicing #alteredpremrnasplicing

In this episode, Jean Claude Katte discusses specificities of type 1 diabetes in sub-Saharan Africa.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #africa #subsaharanafrica

In this episode, Laura Jacobsen discusses Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #treatment #immunotherapy #immunotherapytrials #clinicaltrials #treatmentefficacy #earlymetabolicendpoints

In this episode, Farooq Syed and Preethi Krishnan discusses β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #betacells #pathogenesis #diabetespathogenesis #microRNA #miRNA #molecularhub #biomarkers #diabetesbiomarkers

In this episode, Jay Sosenko discusses Metabolic Endpoints for Type 1 Diabetes Prevention Trials Are Not as Simple as They Seem.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #metabolics #metabolism #endpoints #diabetesprevention #preventiontrials #trials

In this episode, Jason Bini discusses quantitative PET imaging in humans of Pancreatic Beta Cell Mass and Function in vivo.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #PET #quantitativePET #petimaging #betacells #pancreas #pancreaticbetacells #invivo #invivoresearch

In this episode, Quin Xie discusses Immune responses to gut bacteria predict disease onset in a Type 1 Diabetes prevention trial.

#gut #immuneresponses #immunology #preventiontrial #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science