Beta Cell Biology

In this episode, Eugenia Vazquez & Decio Eizirik join us to discuss Differential Immune & Apoptosis-Related Gene Signatures in Pancreatic Alpha & Beta Cells Contribute to their Fate in Type 1 Diabetes.

In this episode, Peter Thompson and Jasmine Pipella join us to discuss old dogs, new tricks: T Cells Drive Beta Cell Senescence in Type 1 Diabetes.

In this episode, Kagan Karakus joins us to discuss T-cell receptor sequences targeting beta-cell proteins present in blood across stages of type 1 diabetes development.

In this episode, Nikki Farnsworth joins us to discuss stressed beta-cells contribute to a loss of peri-islet extracellular matrix in type 1 diabetes.

In this episode, Shani Peleg discusses RNA editing deficiency models differential immunogenicity of alpha and beta-cells.

In this episode, Mallory Brayer joins us to discuss the Intertwining Roles of Mechanosensitive Channels, Cellular Stress, and the Proteasome in β-Cell Function.

In this episode, Miguel Serpas joins us to discuss a lymphotoxin beta signature in human type 1 diabetes.

In this episode, Clayton Mathews joins us to discuss identifying real changes in islets and beta cells during progression to type 1 diabetes.

In this episode, Fahd Qadir joins us to discuss from sex to systems: molecular signaling in beta cells and the path to precision diabetes care.

In this episode, Leslie Wagner a PhD candidate in the Linnemann Lab at Indiana University School of Medicine joins us to discuss beta cell heterogeneity in the acute IFN-alpha response.

In this episode, Emily Walker joins us to discuss retrograde mitochondrial signaling governs the identity of metabolic tissues.


#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #type1diabetesresearch #science #mitochondria #retrogradesignaling #signaling #mitochondrialsignaling #mitochondrialDNA #betacells #beta #metabolics #metabolictissues #type2diabetes #type2diabetesresearch

In this episode, Samuel Stephens joins us to discuss Proinflammatory cytokines mediate pancreatic β-cell specific alterations to Golgi integrity via iNOS-dependent mitochondrial inhibition.

#type1diabetes #t1d #thinktank #diabetes #diabetesresearch #research #novel #type1diabetesresearch #betacells #golgi #mitochondrialinhibition #cytokines #proinflammatorycytokines #inflammation

In this episode, Ernesto Nakayasu discusses the Yin and Yang of fatty acids in regulating β-cell inflammation.

In this episode, Mollie Huber discusses Beta Cell Dysfunction During T1D Pathogenesis.

#ScienceTh1nkTank #ScientificResearch #BiomedicalScience #ResearchTalk #Type1Diabetes #BetaCells #DiabetesResearch #T1D #PancreaticIslets #MollieHuberPhD #UFResearch #JoslinDiabetesCenter #UniversityOfFlorida #HumanPancreasSlices #BetaCellFunction #ImmuneCellActivity #T1DPathogenesis

In this episode, Andrew Templin joins us to discuss novel roles for RIP kinases in beta-cell cytotoxicity.

#type1diabetes #type1diabetesresearch #t1d #RIPkinases #kinases #betacell #betacellstress #betacellcytotoxicity

In this episode, Erica Cai joins us to discuss genome-wide in vivo CRISPR screen uncovers ZBED3 as a transcriptional regulator of beta cell vulnerability in type 1 diabetes.


#type1diabetes #type1diabetesresearch #t1d #CRISPR #CRISPRscreen #betacell #betacellvulnerability #transcriptionalregulator #genomewidescreen #invivo #ZBED3

In this episode, Matthew Austin joins us to discuss dysfunctional beta-cell autophagy induces beta-cell stress and enhances islet immunogenicity.

#type1diabetes #type1diabetesresearch #immunogenicity #islet #betacell #betacellstress #autophagy #dysfunction #dysfunctionalbetacells #stress #t1d

In this episode, Madeline McLaughlin joins us to discuss ultra-high resolution imaging enables quantification of beta cell ER.

#type1diabetes #type1diabetesresearch #imaging #highresolutionimaging #ultrahighresolution #quantification #betacell #betacellER #ER #endoplasmicreticulum #t1d

In this episode, Chaitra Rao joins us to discuss the role of EV PD-L1 in Type 1 Diabetes Dynamics during the Indiana University site visit.

#type1diabetes #type1diabetesresearch #EV #extracellularvesicles #PDL1 #diabetesdynamics #t1d #tcells

In this episode, Marjan Slak Rupnik discusses Intracellular Ca2+ flux interactions in beta cells.

#askthexpert #ATE #type1diabetes #t1d #betacells #pancreas #calcium #calciumflux #intracellularcalcium #novel #science #diabetes #diabetesresearch #t1dresearch