Autoimmunity in T1D

In this episode, Iria Gomez-Touriño discusses physiological and pathogenic T cell auto reactivity converge in type 1 diabetes.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #tcrbeta #tcr #tcellreceptor #tcells #repertoire #autoreactivetcells

In this episode, Raghu Mirmira and Sarah Tersey discuss 12-Lipoxygenase Inhibition delays autoimmune diabetes in human gene replacement mice.


#asktheexpert #ATE #type1diabetes #t1d #t1dresearch #diabetesresearch #novel #diabetes #autoimmune #autoimmunediabetes #humangene #mice #micestudies #12LOX

In this episode, multiple presenters join us to Experts Debate: Autoantibodies in T1D: Biomarkers or Mediators of Destruction?

Presenters:
Ake Lernmark, PhD
Eddie James, PhD
Chris Hampe, PhD
lan Sweet, PhD
Sally Kent, PhD

In this episode, Kevin Bode discusses Beta cell engineering to resist and counteract autoimmunity.

#betacells #betacellengineering #autoimmunity #asktheexpert #t1d #immunology #tcell #novel #science

In this episode, Dr. Keiichiro Mine discusses the role of tyrosine kinase 2 in the pathogenesis of Type 1 diabetes.

#asktheexpert #type1diabetes #tyrosinekinase2 #science #geneediting #education #t1d #viralinfection #autoimmunedisease #betacells #tcell #dedifferentiation #islets #pancreas

In this episode, Inna Starskaia in the lab of Dr. Riitta Lahesmaa discusses distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies.


#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #novel #immuneresponse #autoantibodies @zntransporter #autoantibodiesinchildren #turku #TurkuBioscienceCentre

In this episode, Hannah Pizzato discusses Engineering Human Pluripotent Stem Cells to Evade Immunological Rejection.

#novel #asktheexpert #ATE #T1D #diabetes #type1diabetes #human #science #pluripotent #humanpluripotent #engineering #protocol #immunologicalrejection #stemcells #pluripotentstemcells #evade

In this episode, Sergei Pustylnikov discusses autoimmunity applications of a new efficient method for generating the data on T cell antigen specificity and corresponding TCRs.

#TCR #tcellreceptor #tcell #Tcellantigen #antigen #100xbio #efficientmethod #data #autoimmunity #novel #asktheexpert #ATE #T1D #type1diabetes #science

In this episode, Dr. Marika Falcone discusses does autoimmunity against pancreatic islets originate in the gut?

#autoimmunity #pancreas #islets #type1diabetes #t1d #novel #science #asktheexpert #asktheexperts

Drs. Sara Tersey and Raghu Mirmira from the University of Chicago join us to discuss proinflammatory signaling in beta cells that trigger islet autoimmunity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Tarin Bigley joins us to discuss neonatal roseolovirus infection inducing the disruption of thymic tolerance, resulting in autoimmunity and autoantibodies.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Andrea Schietinger joins us to discuss an autoimmune stem-like CD8 T-cell population and how it drives T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Dario Gerace joins us from the Melton Lab at Harvard to discuss engineering immune-evasive stem cell-derived islet cells.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Haiting Ma joins us to discuss a synthetic immune system and how it implicates beta-cell pyroptosis during T-cell mediated autoimmunity.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Dr. Jessica Kenison joins us to discuss re-balancing the immune system and introducing antigen-specific immune tolerance to treat T1D.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/