Substrate-directed biologic amelioration (glucose/glycolysis elimination): a proposed project in NOD mice or other T1D metazoan models

We propose a sophisticated nutrient regime informed by genetics and metabolism that forces alternative carbon source utilization, in lieu of simple sugars like glucose or other types of simple carbohydrates. By harnessing metabolically and genetically directed nutrient substrates in simple, but biochemically sophisticated diet manipulation, it may be possible to effectively eliminate or reduce the problem of blood glucose entirely by eliminating metabolic dependency on glucose for energy. Using our methodology, oxidative phosphorylation could proceed unhindered to generate cellular energy (ATP), irrespective of glycolytic activity. Thus, this approach could eliminate the need for glucose (glycolysis), but maintain anabolic (biosynthetic) output. This technology stands to provide a dietary solution for T1D patients.