RESEARCH FELLOW – Drug screen and mechanistic studies in the genomics of autoimmunity
We have a physiologic drug screen underway that offers a new therapeutic approach to a number of autoimmune diseases (see below). The candidate would assume leadership of this project, by overseeing the plans underway, developing new high throughput assays, and working out the mechanisms of drug action for the more interesting compounds. In addition, genomic technologies (ChIP-seq, EMSA, DAPA, ATAC-seq, DNA methylation, and others) are being applied in Dr. Harley’s laboratory to reconcile genetic associations with the environmental causes of idiopathic autoimmune disorders with the goal to elucidate mechanisms initiating these pathological processes. The candidate would join a team that has uncovered unexpected and powerful associations of transcription factors with genetic loci, with the goal to establish the genetic mechanisms. The team in place has the strategic, informatic, clinical, and technical expertise to provide strong support for the candidate in addition to the other resources and personnel of the Center for Autoimmune Genomics and Etiology (CAGE). The disorders with direct relevance to this position include lupus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, inflammatory bowel disease, chronic lymphocytic leukemia, Hodgkin’s disease, and many others (Nat Genet. 50:699, 2018).
About Cincinnati Children’s
Cincinnati Children’s Hospital Medical Center is a premier pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support services and facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation.
Post-doctoral research fellows at Cincinnati Children’s are valued for their unique interests and strengths, and are supported by our institution’s strong programming for post-docs through the Office of Postdoctoral Affairs and the Office of Academic Affairs and Career Development. Mentoring, support for international students and an emphasis on crafting high-quality grant proposals are only a few of the features that set our program apart. Cincinnati Children’s is a respected part of the broader, and very vibrant, Cincinnati community. With a thriving arts scene, numerous festivals celebrating music and food, a passionate fan following for our college and professional sports teams, and a variety of opportunities for outdoor activities, our region is truly a great place to work and live.
Major Duties And Responsibilities
- Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques.
- Draft, write, and edit scientific reports, papers, journal articles, and abstracts.
- Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments.
- Develop, set-up, and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats.
- Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.
- Maintain an integral role in the laboratory’s meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars.
- Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel.
- Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
- Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests; track funding, maintain accurate balance, and resolve any discrepancies.
- Follow policies and procedures governing the handling of confidential information as defined by Cincinnati Children’s mission and applicable laws and regulations. Ensure timeliness, accuracy, availability, and security of information.
- Perform routine procedures, including the collection and analysis of research data, which may affect decisions regarding future patient care.
- Provide services in a manner to be regularly and conveniently available to meet the needs of Cincinnati Children’s research initiatives as determined by department management and Cincinnati Children’s governing body.
- Maintain currency in field through continuing education, literature and seminars. Implement this knowledge into the Department.
- Recommend approaches for improvement activities, recommend and perform new processes, collect and measure data, develop processes based on performance, and communicate results.
- Ensure that work areas are organized and present a safe, accessible, effective and efficient environment. Manage attendance at required Cincinnati Children’s training sessions, including radiation safety, laboratory safety, bloodborne pathogens, and OSHA. Comply with Infection Control policies and procedures.
- Participate in establishing job requirements and goals; perform duties at the desired level of competency.
- Understand, adhere to, and model Core Standards as defined organizationally and specifically within the department/unit.
- Perform other duties as assigned.
EDUCATION/ WORK EXPERIENCE: Ph.D. in related discipline, MD, or equivalent required.
The ideal candidate will have a PhD with a familiarity of genomic molecular laboratory methods (e.g., ChIP-seq, CRISPR-Cas9, EMSA, DAPA, etc.) and be computationally sophisticated. Preference will be given to candidates who have experience managing large data sets, the analysis of next generation sequencing data, and data mining. Of course, demonstrated scholarly productivity through discovery and publication is also important.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
United States-Ohio-Cincinnati-Burnet Building Location S