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The Immunomodulation and Translational Research Program in Department of Child Health, University of Missouri focuses on the development of novel biologics and their targeted delivery using various vehicles for immunomodulation to prevent and treat immune-based disorders with particular focus on transplantation, autoimmunity, and cancer. Duties for this Position include: i) develop, execute, and evaluate experiments assessing immunomodulatory efficacy of select biologics for the prevention and treatment of autoimmunity with particular focus on type 1 diabetes (NOD and islet transplantation); ii) islet isolation, characterization, and transplantation; iii) stem-cell-derived beta cell characterization and transplantation; iv) produce, analyze, and organize data for oral presentations at local, national, and international meetings as well as for grant submissions; v) keep detailed record of experimental results, write manuscripts, and publish them in peer-reviewed journals; vi) contribute to ongoing research by active participation in lab discussions, training graduate students and technical personnel for desired techniques as needed.
Essential Duties & Responsibilities
Design and conduct studies that use novel biologics to modulate the immune response as a means of preventing type 1 diabetes (NOD) and treating with islet or stem cell-derived beta cells. The research will involve the production of recombinant proteins, generation of humanized mouse models for islet transplantation, and functional qualification of islets using various in vitro assays. Immune monitoring using flow cytometry, RT-qPCR, microarrays, immunohistochemistry, and confocal microscopy. Further duties include, preparation of scientific publications, assistance with grant applications, and provide technical teaching/training support to graduate students, postdoctoral fellows, and technicians.
Ph.D., M.D. or D.V.M. This position requires a minimum of 3 years of basic laboratory experience and expertise in immunology with focus on autoimmunity, preferably type 1 diabetes, working with rodents, mammalian tissue culture, DNA and RNA isolation, qRT-PCR, microarrays, RNA-seq, tetramer staining.
Effective oral and written and interpersonal communications skills as well as proficiency in word, excel, power point, and statistical software’s.
Expertise in NOD model, islet isolation and functional characterization, cell culture, multiparameter flow cytometry, basic molecular immunological techniques, and immunochemistry. Handling mice and performing various manipulations including injections.
This position is eligible for University benefits. The University offers a comprehensive benefits package, including medical, dental and vision plans, retirement, and educational fee discounts. For additional information on University benefits, please visit the Faculty & Staff Benefits website at http://www.umsystem.edu/totalrewards/benefits
The University of Missouri is fully committed to achieving the goal of a diverse and inclusive academic community of faculty, staff and students. We seek individuals who are committed to this goal and our core campus values of respect, responsibility, discovery and excellence.
Equal Employment Opportunity
Equal Opportunity is and shall be provided for all employees and applicants for employment on the basis of their demonstrated ability and competence without unlawful discrimination on the basis of their race, color, national origin, ancestry, religion, sex, pregnancy, sexual orientation, gender identity, gender expression, age, disability, protected veteran status, or any other status protected by applicable state or federal law. This policy shall not be interpreted in such a manner as to violate the legal rights of religious organizations or the recruiting rights of military organizations associated with the Armed Forces or the Department of Homeland Security of the United States of America. For more information, call the Vice Chancellor of Human Resource Services/Affirmative Action officer at 573-882-4256.
To request ADA accommodations, please call the Disability Inclusion and ADA Compliance Manager at 573-884-7278.