Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk
https://www.biorxiv.org/content/10.1101/2021.01.13.426472v1
Paper of the Week
Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics Changyang Linghu 16 Shannon L. Johnson 16 Pablo A. Valdes Or A. Shemesh Won Min Park Demian…
Making trophoblasts (Dong et al)
Derivation of trophoblast stem cells from naïve human pluripotent stem cells Chen Dong, Mariana Beltcheva, Paul Gontarz, Bo Zhang, Pooja Popli, Laura A Fischer, Shafqat…
Stem cells become cells with trophoblast qualities (Cinkornpumin et al)
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome Jessica K.Cinkornpumin1Sin YoungKwon1YixinGuo4IshtiaqueHossain1JacintheSirois12Colleen S.Russett1Hsin-WeiTseng1HiroakiOkae5TakahiroArima5Thomas F.Duchaine12WanluLiu3 William A.Pastor12 Stem Cell…
Hypoxia in places other than beta transplants (Soares et al)
https://pubmed.ncbi.nlm.nih.gov/29105383/ Hypoxia and Placental Development Michael J Soares 1 2 3, Khursheed Iqbal 1, Keisuke Kozai 1 Affiliations 1Institute for Reproduction and Perinatal Research, Department of Pathology and Laboratory Medicine, University of…
How lncRNA works in nature’s implant, the placenta (Tongtong et al)
Figure 4. PIWIL is essential for the invasion and proliferation of trophoblasts. LncRNA H19X is required for placenta development and angiogenesis through regulating a noncoding…
NKs at work in other implantation sites (Sojka et al)
Uterine Natural Killer Cells Dorothy K. Sojka,* Liping Yang, and Wayne M. Yokoyama https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504766/
Testing islet cells with microelectrode array (Alassaf et al)
Microelectrode Array based Functional Testing of Pancreatic Islet Cells Ahmad Alassaf 1 2 3, Matthew Ishahak 1 2, Annie Bowles 1 2, Ashutosh Agarwal 1 2 1Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146,…
Precision nanoparticles for drug delivery (Mitchell et al)
NATURE REVIEWS: Engineering precision nanoparticles for drug delivery,Michael J. Mitchell 1,2,3,4,5 ✉, Margaret M. Billingsley1, Rebecca M. Haley 1, Marissa E. Wechsler6, Nicholas A. Peppas6,7,8,9,10 ✉ and Robert Langer https://mitchell-lab.seas.upenn.edu/wp-content/uploads/2020/12/s41573-020-0090-8.pdf
“Feathering the nest” for islet transplant (Liu et al)
A novel prevascularized tissue-engineered chamber as a site for allogeneic and xenogeneic islet transplantation to establish a bioartificial pancreas Yanzhuo Liu , Maozhu Yang , Yuanyuan Cui,…