injectable mesh electronics

Stimulating Your Brain With Research on Injectable Mesh Electronics

Previous studies investigating injectable electronics into the brain to help treat diseases have used conventional polymer thin-film probes. This technique has led to a distinct chronic immune response and tissue remodeling, resulting in more modern strategies coming to light. These techniques include mesh electronic injections with a focus on reduced diameter needles for probe implantation to help avoid chronic immune responses. Thin diameter probed mesh injections can be applied on challenging areas of implantation and encourage future research on other injectable mesh electronics.

Mesh electronics vs. polymer thin-film probes

Mesh probes:

  •   more similar to biological tissue
  •   less inflammation
  •   reduced damage to surrounding neurons

Thin-film probes:

  •   high bending stiffness
  •   increase accumulation of astrocytes

Conclusions

Compared to conventional polymer thin-film probes, injectable mesh probes appear to have less chronic immune responses and tissue remodeling. This includes a reduced amount of tissue inflammation and damage to nearby neurons; important aspects in both brain activation and healing after probe implantation. A reduced probe diameter can also assist in chronic immune response reduction from the probe injection.

Applications

Mesh injections, specifically those focusing on reduced diameter probes, can be used for specific, difficult areas of implantations. The spinal cord and neuromuscular junctions are common research focal points and can be involved in future studies with thin diameter probe electronic mesh injections. Reduced diameter probes create new advantages and opportunities for brain activity mapping in future research.

Bottom Line

Mesh electronics should be injected using reduced diameter probes for improved chronic immune response after probe implantation.

Sources:

  • Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics
    • 2019, Harvard University
  • Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain
    • 2017, Harvard University

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